Protective effect of ascorbic acid on dexamethasone-induced  intraocular hypertension in rabbit

LIU Zhaohui; et al

doi:10.13406/j.cnki.cyxb.2004.01.016

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Protective effect of ascorbic acid on dexamethasone-induced intraocular hypertension in rabbit

更新时间：2024-01-17

- Protective effect of ascorbic acid on dexamethasone-induced intraocular hypertension in rabbit
- Journal of Chongqing Medical University Issue 1, Pages: 51-54(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院眼科
  2. 重庆医科大学临床学院眼科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.01.016
  CLC： R775
- Published：2004，
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[1]刘朝晖,游世平.抗坏血酸在兔类固醇性高眼压中保护作用的研究[J].重庆医科大学学报,2004(01):51-54.

LIU Zhaohui, et al. Protective effect of ascorbic acid on dexamethasone-induced intraocular hypertension in rabbit. [J]. Journal of Chongqing Medical University (1):51-54(2004)
[1]刘朝晖,游世平.抗坏血酸在兔类固醇性高眼压中保护作用的研究[J].重庆医科大学学报,2004(01):51-54. DOI： 10.13406/j.cnki.cyxb.2004.01.016.

LIU Zhaohui, et al. Protective effect of ascorbic acid on dexamethasone-induced intraocular hypertension in rabbit. [J]. Journal of Chongqing Medical University (1):51-54(2004) DOI： 10.13406/j.cnki.cyxb.2004.01.016.

摘要

目的 :研究抗坏血酸在类固醇性高眼压发病中的作用。方法 :2 0只兔分为四组

每组 5只。观察四组实验动物眼压变化与时间关系。测定房水抗坏血酸浓度

眼球制作病理切片。结果 :单独使用地塞米松组兔眼压显著升高

房水中抗坏血酸浓度明显低于其它组 ;联合使用地塞米松及抗坏血酸眼压略有升高

后期有下降

小梁网出现轻微病理改变。结论 :局部使用皮质类固醇药物治疗时

同时局部给予抗坏血酸

可延缓和减轻类固醇性高眼压的发生。

Abstract

Objective:To investigate the protective effect of ascorbic acid on dexamethasone-induced intraocular hypertension in rabbits.Methods:20 white rabbits were divided into four groups

with 5 in each one group.Every group was treated differently.Their intraocular pressure (IOP) and ascorbic acid concentration of aqueous humors were detected.Their eyeballs were studied for morphologic analysis.Results:There were statistical difference in IOP and ascorbic acid concentration of aqueous humors between the trial group subconjunctivally injected with dexamethasone and control groups.Their histological changes were significantly different.Conclusion:Subconjunctival injection of ascorbic acid can delay and alleviate the dexamethasone-induced intraocular hypertension in rabbits.

关键词

抗坏血酸眼压地塞米松小梁网

Keywords

Ascorbic acidIntraocular pressuredexamethasoneTrabecular meshwork

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