A novel antiapoptosis gene,survivin,expression in bladder transitional cell cancer

HE Weiyang; et al

doi:10.13406/j.cnki.cyxb.2004.01.013

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A novel antiapoptosis gene,survivin,expression in bladder transitional cell cancer

更新时间：2024-01-17

- A novel antiapoptosis gene,survivin,expression in bladder transitional cell cancer
- Journal of Chongqing Medical University Issue 1, Pages: 41-44(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院泌尿外科
  2. 济宁医学院外总教研室
  3. 重庆医科大学临床学院泌尿外科,重庆,400046
  4. ,济宁,272033
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.01.013
  CLC： R737.14
- Published：2004，
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[1]何卫阳,苟欣,祝海洲,詹自力.凋亡抑制基因survivin在膀胱移行细胞癌中表达的初步研究[J].重庆医科大学学报,2004(01):41-44+50.

HE Weiyang, et al. A novel antiapoptosis gene,survivin,expression in bladder transitional cell cancer. [J]. Journal of Chongqing Medical University (1):41-44(2004)
[1]何卫阳,苟欣,祝海洲,詹自力.凋亡抑制基因survivin在膀胱移行细胞癌中表达的初步研究[J].重庆医科大学学报,2004(01):41-44+50. DOI： 10.13406/j.cnki.cyxb.2004.01.013.

HE Weiyang, et al. A novel antiapoptosis gene,survivin,expression in bladder transitional cell cancer. [J]. Journal of Chongqing Medical University (1):41-44(2004) DOI： 10.13406/j.cnki.cyxb.2004.01.013.

摘要

目的 :探讨新的凋亡抑制基因survivin在膀胱移行细胞癌（bladdertransitionalcellcancer

BTCC）中的表达

及其与p5 3、bcl- 2和ki6 7基因表达的相关性。方法 :应用免疫组织化学链霉抗生物素蛋白—过氧化物酶连接法（SP法）

检测sur vivin、bcl- 2、p5 3和ki6 7在 5 8例BTCC中的表达

另选 10例癌旁正常组织作对照。结果 :survivin基因在癌旁正常组织中无表达

而在BTCC中呈高表达

survivin的表达与BTCC的临床分期和病理分级密切相关。 5 8例BTCC中

4 1例表达阳性

占70 .7%。同时发现survivin的表达与 p5 3、bcl- 2、ki6 7的表达也密切相关。结论 :survivin基因的过度表达单独或和 p5 3、bcl-2、ki6 7协同在BTCC的发生发展中起重要作用

其过度表达提示BTCC预后不良。survivin可能会成为膀胱移行细胞癌一个新的诊断指标和治疗的靶点。

Abstract

Objective:To study the expression of a novel inhibitor gene of apoptosis

survivin

in bladder transitional cell cancer

and its relationship with the expression of p53

bcl-2 and ki67 genes.Methods:Using streptavidin-biotin peroxidase(SP) method

we examined the expression of survivin

p53

bcl-2 and ki67 proteins in 10 normal bladder tissues and 58 bladder transitional cell cancer tissues.Results:Survivin was expressed in 41 of 58(70.7%) cases of BTCC.In contrast

normal bladder epithelium did not express survivin.Overexpression of survivin was related to the tumor grade and clinical stage.The expression of survivin was strongly correlated with p53.bcl-2 and ki67 expression.Conclusion:Apoptosis inhibition by survivin

alone or in cooperation with p53 and bcl-2 may participate in the onset and progression of bladder transitional cell cancer.Survivin could be a new diagnostic/therapeutic target in bladder tranditional cell cancer.

关键词

膀胱肿瘤免疫组织化学SurvivinBcl-2p53Ki67

Keywords

Bladder neoplasmsImmunohistochemical methodsSurvivinBcl-2p53Ki67

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