Inhibitory effect of urinary trypsin inhibitor on protease activity in the colonic tissues of ulcerative colitis rats

ZHU Daihua; et al

doi:10.13406/j.cnki.cyxb.2004.01.012

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Inhibitory effect of urinary trypsin inhibitor on protease activity in the colonic tissues of ulcerative colitis rats

更新时间：2024-01-17

- Inhibitory effect of urinary trypsin inhibitor on protease activity in the colonic tissues of ulcerative colitis rats
- Journal of Chongqing Medical University Issue 1, Pages: 38-40(2004)
- 作者机构：
  
  1. 重庆医科大学第二临床学院普外科
  2. 重庆医科大学第二临床学院普外科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.01.012
  CLC： R574.62
- Published：2004，
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[1]朱代华,张兴明,郭丹.尿胰蛋白酶抑制剂对鼠溃疡性结肠炎结肠组织中蛋白酶活性的抑制作用[J].重庆医科大学学报,2004(01):38-40.

ZHU Daihua, et al. Inhibitory effect of urinary trypsin inhibitor on protease activity in the colonic tissues of ulcerative colitis rats. [J]. Journal of Chongqing Medical University (1):38-40(2004)
[1]朱代华,张兴明,郭丹.尿胰蛋白酶抑制剂对鼠溃疡性结肠炎结肠组织中蛋白酶活性的抑制作用[J].重庆医科大学学报,2004(01):38-40. DOI： 10.13406/j.cnki.cyxb.2004.01.012.

ZHU Daihua, et al. Inhibitory effect of urinary trypsin inhibitor on protease activity in the colonic tissues of ulcerative colitis rats. [J]. Journal of Chongqing Medical University (1):38-40(2004) DOI： 10.13406/j.cnki.cyxb.2004.01.012.

摘要

目的 :确定尿胰蛋白酶抑制剂（UTI）对鼠溃疡性结肠炎（UC）结肠组织中蛋白酶的作用。方法 :用 18%的DNBS乙醇溶液 0 .2 5ml灌肠

在Wistar大鼠上建立UC模型 ;经尾静脉注射UTI ;用明胶酶谱法测定病变结肠组织中的蛋白酶活性。结果 :经UTI处理后

鼠UC结肠组织中蛋白酶活性仅为对照组的 1/3。结论 :UTI能显著降低鼠UC结肠组织中蛋白酶活性。

Abstract

Objective:To determine the effect of urinary trypsin inhibitor(UTI)on protease activity in the colonic tissues of ulcerative colitis(UC) rats.Methods:The experimental UC was induced in Wistar rats by enema with 0.25ml of 18% 2

4-dinitrobenzenesulfonic acid (DNBS) dissolved in ethanol.UTI was injected into the rats through the caudal vein.Protease activity present in colonic tissues was determined on gelatin zymograms.Results:The protease activity which presented in colonic tissues of the group treated with UTI was only 1/3 that of the control.Conclusion:The protease activity decreased significantly after we treated the rats with UTI.

关键词

尿胰蛋白酶抑制剂结肠炎溃肠性疾病模型动物鼠

Keywords

Urinary trypsin inhibitorUlcerative colitisProteaseDisease modelanimalRat

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A DNBS-induced model of ulcerative colitis in rats

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