A study on the pathological efficacy of lamivudine  in the treatment of chronic hepatitis B

YANG Chun; et al

doi:10.13406/j.cnki.cyxb.2004.01.011

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A study on the pathological efficacy of lamivudine in the treatment of chronic hepatitis B

更新时间：2024-01-17

- A study on the pathological efficacy of lamivudine in the treatment of chronic hepatitis B
- Journal of Chongqing Medical University Issue 1, Pages: 34-37(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院感染科
  2. 北京大学临床药理研究所
  3. 重庆医科大学病理学研究室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.01.011
  CLC： R512.62
- Published：2004，
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[1]杨春,肖永红,管小琴.拉米夫定治疗慢性乙型肝炎的肝组织病理学研究[J].重庆医科大学学报,2004(01):34-37.

YANG Chun, et al. A study on the pathological efficacy of lamivudine in the treatment of chronic hepatitis B. [J]. Journal of Chongqing Medical University (1):34-37(2004)
[1]杨春,肖永红,管小琴.拉米夫定治疗慢性乙型肝炎的肝组织病理学研究[J].重庆医科大学学报,2004(01):34-37. DOI： 10.13406/j.cnki.cyxb.2004.01.011.

YANG Chun, et al. A study on the pathological efficacy of lamivudine in the treatment of chronic hepatitis B. [J]. Journal of Chongqing Medical University (1):34-37(2004) DOI： 10.13406/j.cnki.cyxb.2004.01.011.

摘要

目的 :观察拉米夫定治疗前后

慢性乙肝病人肝组织学及肝组织内HBV标志物的改变。方法 :35例病人予拉米夫定 10 0mg/d

连用 1年。行治疗前后肝穿刺活检

切片HE染色

Knodell评分

用免疫组化法检测肝细胞内HBsAg、HBcAg、α -平滑肌肌动蛋白（α -SMA）。结果 :治疗后肝活检示 4 1.18%患者肝组织学活动指数得以改善

汇管区坏死、门静脉炎症及纤维化明显改善。免疫组化检测示血清HBeAg转换组肝组织内HBcAg、α -SMA的表达明显减少

HBsAg的表达无显著性改变。结论 :拉米夫定 10 0mg/天治疗 1年可减轻肝脏炎症坏死和肝纤维化程度

延缓肝纤维化的进展。一旦有HBeAg血清学转换

肝组织HBcAg、α -SMA表达减少。

Abstract

Objective:To investigate hepatic pathohistological changes(including pathology

HBV markers in liver tissue) in patients with chronic hepatitis B treated with lamivudine.Methods:35 patients of chronic hepatitis B were randomly selected and administered with 100mg lamivudine orally daily for 1 year.The needle biopsy of liver were performed before and after treatment.The routine HE stained liver tissue sections were evaluated and Knodell pathological score were done.HBsAg

HBcAg

α-SMA in liver tissue were examined by immunohistochemisty method.Results:After 1 year histological assessment revealed that activity index of hepatic histology in 41.18% patients had a significant decrease

while necrosis in portal area

portal vein phlebitis and fibrosis were oboviously alleviated.The liver immunohistochemistry examination showed that HBcAg and α-SMA in liver decreased significantly in the patients with HBeAg seroconversion

but HBsAg had no obvious alteration.Conclusion:These results suggest that lamivudine(100mg/d) alleviate the inflammation degree

slow down the development of liver fibrosis after 1 year therapy.Once HBeAg seroconversion appears

HBcAg and α-SMA in liver decreased.

关键词

慢性乙型肝炎拉米夫定组织学免疫组织化学

Keywords

chronic hepatitis BLamivudineHistologyimmunohistochemistry

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