Changes of plasm endothelin-1 in rabbits with alcoholism

XIE Juan; et al

doi:10.13406/j.cnki.cyxb.2004.01.007

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Changes of plasm endothelin-1 in rabbits with alcoholism

更新时间：2024-01-17

- Changes of plasm endothelin-1 in rabbits with alcoholism
- Journal of Chongqing Medical University Issue 1, Pages: 21-23(2004)
- 作者机构：
  
  1. 重庆医科大学基础医学院核医学教研室
  2. 重庆医科大学基础医学院核医学教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.01.007
  CLC： R595.6
- Published：2004，
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[1]谢娟,郭坤亮,李少林.酒精中毒家兔血浆内皮素-1水平变化[J].重庆医科大学学报,2004(01):21-23.

XIE Juan, et al. Changes of plasm endothelin-1 in rabbits with alcoholism. [J]. Journal of Chongqing Medical University (1):21-23(2004)
[1]谢娟,郭坤亮,李少林.酒精中毒家兔血浆内皮素-1水平变化[J].重庆医科大学学报,2004(01):21-23. DOI： 10.13406/j.cnki.cyxb.2004.01.007.

XIE Juan, et al. Changes of plasm endothelin-1 in rabbits with alcoholism. [J]. Journal of Chongqing Medical University (1):21-23(2004) DOI： 10.13406/j.cnki.cyxb.2004.01.007.

摘要

目的 :探讨酒精中毒家兔血浆内皮素 - 1（ET - 1

pg/ml）水平的变化。方法 :选用家兔 2 4只

随机分为 2组。实验组采用灌胃法给予家兔含乙醇 5 0 %的烈性白酒 8ml/ （kg·d）

对照组给等量生理盐水

分别于 1、2、3、4、5、6个月取血检测血浆ET - 1、丙二醛（MDA）和超氧化物歧化酶（SOD）的变化。结果 :灌胃 1、2、3月时ET - 1和MDA含量变化无显著性差异（P >0 .0 5 ）

4～ 6月时ET - 1和MDA逐渐增加（4个月P <0 .0 5

5、6月P <0 .0 1）

ET - 1与MDA含量呈正相关性（r =0 .6 4

P<0 .0 1）。 1、2月时SOD变化无显著性差异（P >0 .0 5 ）

3～ 6月时SOD活性逐渐降低（3、4月时P <0 .0 5

5、6月P <0 .0 1）

ET - 1与SOD呈负相关性（r =- 0 .2 4

P <0 .0 5 ）。结论 :长期过量饮酒引起的氧自由基作用增强

血管内皮素 - 1增加

导致血管内皮损伤

可能在酒精中毒的发病机制过程中发挥重要作用。

Abstract

Objective:To explore the changes in rabbit endothelin-1 induced by alcoholism.Methods:24 rabbits were chosen and divided into two groups randomly.In experimental group wine containing 50% of alcohol at dosage of 8mL/(kg·d) was given

and the same dose of NS for controls by pouring into stomach with a plastic tube for 6 months and to observe the changes of ET-1

superoxide dismutase(SOD)

malondialdehyde(MDA) in plasma in 1-6 months.Results:In 1-3 months

the content of ET-1 and MDA did not change significantly (P>0.05)

but it increased gradually in 4～6 months (at 4 month P<0.05

at 5

6monthP<0.01).The content of ET-1 in the experimental group was positively correlated to MDA(r=0.64

P<0.01).The activity of SOD did not change remarkably in 1～2 month(P>0.05)

but it decreased gradually in 3～6 month(3

4month P<0.05

5、6month P<0.01).The content of ET-1 in the experimental group was negatively correlated to the activity of SOD (r=-0.24

P<0.05).Conclusion:Long-term excessive intake of wine increase oxygen-derived free radicals and ET-1

and lead to injury of endothelium of blood vessel

which may play a key role in the process of pathogenesis in alcoholism.

关键词

酒精中毒内皮素-1丙二醛超氧化物歧化酶

Keywords

Alcoholismendothelin-1Superoxide dismutaseMalondialdehyde

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