Acute lung injury induced by endotoxic shock and imbalance of Th1/Th2 type of cytokines

ZHANG Mingjing; et al

doi:10.13406/j.cnki.cyxb.2004.01.005

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Acute lung injury induced by endotoxic shock and imbalance of Th1/Th2 type of cytokines

更新时间：2024-01-17

- Acute lung injury induced by endotoxic shock and imbalance of Th1/Th2 type of cytokines
- Journal of Chongqing Medical University Issue 1, Pages: 15-17(2004)
- 作者机构：
  
  1. 重庆医科大学儿科学院
  2. 重庆医科大学儿科学院,重庆,400014
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.01.005
  CLC： R631.4
- Published：2004，
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[1]张明静,王兴勇,卢仲毅,匡凤梧.内毒素休克性肺损伤与IFN-γ/IL-4失衡[J].重庆医科大学学报,2004(01):15-17.

ZHANG Mingjing, et al. Acute lung injury induced by endotoxic shock and imbalance of Th1/Th2 type of cytokines. [J]. Journal of Chongqing Medical University (1):15-17(2004)
[1]张明静,王兴勇,卢仲毅,匡凤梧.内毒素休克性肺损伤与IFN-γ/IL-4失衡[J].重庆医科大学学报,2004(01):15-17. DOI： 10.13406/j.cnki.cyxb.2004.01.005.

ZHANG Mingjing, et al. Acute lung injury induced by endotoxic shock and imbalance of Th1/Th2 type of cytokines. [J]. Journal of Chongqing Medical University (1):15-17(2004) DOI： 10.13406/j.cnki.cyxb.2004.01.005.

摘要

目的 :探讨内毒素休克肺损伤与TH1/TH2平衡的关系。方法 :采用颈静脉注入LPS复制大鼠急性肺损伤模型

用ELISA法检测其外周血单个核细胞（PBMC）产生IFN -γ、IL - 4水平及IFN -γ/IL - 4比值。结果 :与正常对照组相比

急性肺损伤组外周血PBMC产生IFN -γ水平

IFN -γ/IL - 4比值明显升高（P <0 .0 5 ;P <0 .0 0 1）

而IL - 4水平差异无显著性（P >0 .0 5 ）

肺组织病理切片显示大鼠发生ALI。结论 :LPS休克肺损伤时

体内存在Th1/Th2类细胞因子水平失衡。

Abstract

Objective:To investigate the type of imbalance of cytokines and its relations to the ALI induced by endotoxic shock.Methods:ALI rats model was made by injcting lipopolysacharide(LPS) into jugular vein.Enzyme-linked immunosorbent assay(ELISA) was employed to measure interferon-γ(IFN-γ) level

interleukin-4(IL-4) level and the ratio of IFN-γ/IL-4.Pathological examination was made under optical microscope at the same time.Results:Compared with normal control group

the IFN-γ level

the ratio of IFN-γ/IL-4 increased significantly(P<0.05;P<0.001)whereas IL-4 level didnt′t change obviously(P>0.05).Pathological examination of lung tissue proved the presence of ALI in rats.Conclusion:The imbalance of Th1/Th2 type cytokines exists in the endotoxic shock-induced ALI.

关键词

急性肺损伤Th1/Th2内毒素休克细胞因子

Keywords

acute lung injuryTh1/Th2Endotoxic shockcytokine

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