Changes of soluble Fas and soluble Fas ligand in infertile patients with endometriosis

LING Huhua; et al

doi:10.13406/j.cnki.cyxb.2004.01.002

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Changes of soluble Fas and soluble Fas ligand in infertile patients with endometriosis

更新时间：2024-01-17

- Changes of soluble Fas and soluble Fas ligand in infertile patients with endometriosis
- Journal of Chongqing Medical University Issue 1, Pages: 5-7(2004)
- 作者机构：
  
  1. 重庆医科大学临床学院妇产科
  2. 重庆医科大学临床学院妇产科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2004.01.002
  CLC： R711.6
- Published：2004，
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[1]令狐华,徐小蓉,骆建云,庄琳,卞度宏.子宫内膜异位症不孕与血清和腹腔液中可溶性Fas和可溶性Fas配体的关系[J].重庆医科大学学报,2004(01):5-7.

LING Huhua, et al. Changes of soluble Fas and soluble Fas ligand in infertile patients with endometriosis. [J]. Journal of Chongqing Medical University (1):5-7(2004)
[1]令狐华,徐小蓉,骆建云,庄琳,卞度宏.子宫内膜异位症不孕与血清和腹腔液中可溶性Fas和可溶性Fas配体的关系[J].重庆医科大学学报,2004(01):5-7. DOI： 10.13406/j.cnki.cyxb.2004.01.002.

LING Huhua, et al. Changes of soluble Fas and soluble Fas ligand in infertile patients with endometriosis. [J]. Journal of Chongqing Medical University (1):5-7(2004) DOI： 10.13406/j.cnki.cyxb.2004.01.002.

摘要

目的 :分析可溶性Fas及可溶性Fas配体在子宫内膜异位症所致不孕中的可能意义。方法 :采用酶联免疫吸附双抗体夹心法

检测 2 0例Ⅰ～Ⅱ期子宫内膜异位症不孕患者血清及腹腔液中可溶性Fas及可溶性Fas配体溶液

并与 14例慢性盆腔炎致不孕者和 16例健康生育者比较。结果 :子宫内膜异位症不孕患者血清和腹腔液内溶性Fas配体浓度（分别为 175 .0 9± 80 .5 0pg/ml和 2 84 .5 0± 15 2 .38pg/ml）

显著高于健康生育对照（血清 16 .13± 11.75 pg/ml;腹腔液 8.84± 2 .31pg/ml）及慢性盆腔炎致不孕者（血清 88.4 7± 4 3.5 5 pg/ml;腹腔液 17.30± 9.6 2 pg/ml）。其可溶性Fas抗原水平（血清 82 8.6 0± 4 2 9.6 5Ppg/ml;腹腔液 349.6± 2 88.89pg/ml）与盆腔炎组（血清 86 8.75± 5 70 .4 8pg/ml;腹腔液 181.76± 15 7.78pg/ml）及健康生育组（血清 82 2 .2 6±12 9.12 pg/ml;腹腔液 318.4 2± 14 5 .16 pg/ml）相比

均无统计学显著差别。结论 :可溶性Fas配体与子宫内膜异位症所致不孕具有显著相关性

可能在其盆腔局部微环境改变致不孕中具重要意义。

Abstract

Objective:To investigate the relationship between the level of soluble Fas antigen(sfas) and soluble Fas ligand(sFasL) and endometriosis associated infertility.Methods:The sfas and sFasL level in sera and peritoneal fluid of infertile women with endometriosis were assessed with enzyme-linked immunosorbent assay

and were compared with those of 14 infertile women resulting from chronic pelvic infectious disease and 16 fertile controls.Results:The sFasL levels(175.09±80.50pg/ml in sera and 284.50±152.38pg/ml in peritoneal fluid) were significantly higher in infertile patients with endometriosis than those of infertile controls(88.47±43.55pg/ml in sera and 17.30±9.62pg/ml in peritoneal fluid) and fertile controls(16.13±11.75pg/ml in sera and 8.84±2.31pg/ml in peritoneal fluid).Compared with the levels of sfas in infertile women resulting from pelvic infectious disease(868.75±570.48pg/ml in sera and 181.76±157.78pg/ml in peritoneal fluid) and fertile control group(822.26±129.12pg/ml in sera and 318.42±145.16pg/ml in peritoneal fluid)

the values of sfas in infertile patients with endometriosis(828.60±429.65pg/ml in sera and 349.6±288.89pg/ml in peritoneal fluid) have no significant difference.Conclusion:Endometriosis-related infertility has great association with the level of sFasL

and sFasL may play a key role in the local homeostatic regulation in endometriosis and in turn result in the development of its associated infertility.

关键词

子宫骨膜异位不孕FasFas配体（sFasL）

Keywords

EndometriosisinfertilityFasFas ligand(sFasL)

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重庆医科大学第二临床学院内科

Department of Internal Medicine, the Second College of Clinical Medicine, Chongqing Medical University

重庆医科大学临床学院妇产科,重庆医科大学临床学院妇产科,四川省妇幼保健院,重庆市第四人民医院,重庆医科大学第二临床学院重庆　400016,重庆　400016

重庆医科大学基础医学院组胚教研室

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