Effect of trimetazidine on cardiac systolic and diastolic function in patients with chronic congestive heart failure due to coronary artery disease

LIU Dong; et al

doi:10.13406/j.cnki.cyxb.2003.06.038

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Effect of trimetazidine on cardiac systolic and diastolic function in patients with chronic congestive heart failure due to coronary artery disease

更新时间：2024-01-17

- Effect of trimetazidine on cardiac systolic and diastolic function in patients with chronic congestive heart failure due to coronary artery disease
- Journal of Chongqing Medical University Issue 6, Pages: 804-806(2003)
- 作者机构：
  
  1. 重庆医科大学第二临床学院心内科
  2. 重庆医科大学第二临床学院心内科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.06.038
  CLC： R541.6
- Published：2003，
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[1]刘东,黄晶,邓昌明,高大中,李增高.曲美他嗪对冠心病心力衰竭患者心脏收缩和舒张功能的影响[J].重庆医科大学学报,2003(06):804-806.

LIU Dong, et al. Effect of trimetazidine on cardiac systolic and diastolic function in patients with chronic congestive heart failure due to coronary artery disease. [J]. Journal of Chongqing Medical University (6):804-806(2003)
[1]刘东,黄晶,邓昌明,高大中,李增高.曲美他嗪对冠心病心力衰竭患者心脏收缩和舒张功能的影响[J].重庆医科大学学报,2003(06):804-806. DOI： 10.13406/j.cnki.cyxb.2003.06.038.

LIU Dong, et al. Effect of trimetazidine on cardiac systolic and diastolic function in patients with chronic congestive heart failure due to coronary artery disease. [J]. Journal of Chongqing Medical University (6):804-806(2003) DOI： 10.13406/j.cnki.cyxb.2003.06.038.

摘要

目的 :探讨曲美他嗪对冠心病慢性心力衰竭患者心脏收缩和舒张功能的影响。方法 :观察冠心病慢性心力衰竭患者4 5例

其中曲美他嗪组 2 3例

对照组 2 2例。分别测定用药前及用药 6月后两组患者的超声心动图心功能指标SV

CIandLVEF

VA/VE。结果 :用药 6月后曲美他嗪组患者的SV

CI及LVEF较对照组显著增高（P <0 .0 5 ）

但VA

VE及VA/VE与对照组相比无显著性差异（P >0 .0 5 ）。结论 :曲美他嗪通过改善缺血心肌细胞的能量代谢

可保护缺血心肌细胞的功能

从而改善心脏的收缩功能。

Abstract

Objective:To investigate the effects of trimetazidine on cardiac systolic and diastolic function in patients with chronic congestive heart failure due to coronary artery disease.Methods:45 patients with chronic congestive heart failure due to coronary artery disease were divided into two groups

23 patients in trimetazidine group and 22 in placebo-control group.The echocardiogram indices of cardiac function of patients in two groups-SV

LVEF

VE and VA/VE were measured before and after treatment.Results:The indexes SV

CI and LVEF were significantly higher in trimetazidine group than those in control group(P<0.05)

but no significant difference in VA

VE and VA/VE was observed between the two groups(P>0.05).Conclusion:Trimetazidine can improve systolic function of ischemic heart by improving the energy metabolism of ischemic heart.

关键词

曲美他嗪冠心病心力衰竭心功能

Keywords

Trimetazidinecoronary artery diseaseheart failurecardiac function

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Related Institution

Cardiovascular Department，The First Affiliated Hospital of Chongqing Medical University

Department of Cardiology，The First Affiliated Hospital of Chongqing Medical University

Department of Endocrinology, The Affiliated Huai'an No.1 People’s Hospital of Nanjing Medical University

Department of ECG, The Affiliated Huai'an No.1 People’s Hospital of Nanjing Medical University

Department of Nephrology, The Affiliated Huai'an No.1 People’s Hospital of Nanjing Medical University

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