Analysis on the factors related to insulin resistance and islet β cell secretory function in subjects with normal glucose tolerance

BAO Bingnan; et al

doi:10.13406/j.cnki.cyxb.2003.06.026

您当前的位置：

首页 >

文章列表页 >

Analysis on the factors related to insulin resistance and islet β cell secretory function in subjects with normal glucose tolerance

更新时间：2024-01-17

- Analysis on the factors related to insulin resistance and islet β cell secretory function in subjects with normal glucose tolerance
- Journal of Chongqing Medical University Issue 6, Pages: 771-774(2003)
- 作者机构：
  
  1. 重庆医科大学临床学院内分泌科
  2. 重庆医科大学流行病学教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.06.026
  CLC： R587
- Published：2003，
扫描看全文
[1]包柄楠,张素华,任伟,李革,卢仙娥,杜娟,陈静,王继旺,马贵成.正常糖耐量人群胰岛素抵抗和胰岛β细胞分泌功能相关因素分析[J].重庆医科大学学报,2003(06):771-774.

BAO Bingnan, et al. Analysis on the factors related to insulin resistance and islet β cell secretory function in subjects with normal glucose tolerance. [J]. Journal of Chongqing Medical University (6):771-774(2003)
[1]包柄楠,张素华,任伟,李革,卢仙娥,杜娟,陈静,王继旺,马贵成.正常糖耐量人群胰岛素抵抗和胰岛β细胞分泌功能相关因素分析[J].重庆医科大学学报,2003(06):771-774. DOI： 10.13406/j.cnki.cyxb.2003.06.026.

BAO Bingnan, et al. Analysis on the factors related to insulin resistance and islet β cell secretory function in subjects with normal glucose tolerance. [J]. Journal of Chongqing Medical University (6):771-774(2003) DOI： 10.13406/j.cnki.cyxb.2003.06.026.

摘要

目的 :探讨影响正常糖耐量（NGT）人群胰岛素抵抗（IR）和胰岛 β细胞分泌功能的相关因素。方法 :对 2 12 0例NGT者

用稳态模式评估法（HOMA）评价胰岛素抵抗和胰岛 β细胞分泌功能。结果 :（1）单因素方差分析表明

不同年龄组的HOMA -IR、HOMA - βcell有显著性差异（P <0 .0 5 ）。（2 ）t检验表明

超重 /肥胖组较正常体重组

中心性肥胖组较非中心性肥胖组、高TG组较正常TG组、高血压组较正常血压组HOMA -IR、HOMA - βcell均有显著性差异（P <0 .0 1）。（3）多元逐步回归分析表明

年龄、BMI、腰围、TG和舒张压是影响HOMA -IR、HOMA - βcell的主要因素。结论 :NGT人群随着年龄、BMI、腰围、TG和血压的增加

IR加重 ;胰岛 β细胞分泌功能随着年龄的增加而减弱

随着BMI、腰围、TG和血压的增加而代偿性增强

以维持正常的糖耐量。

Abstract

Objective:To investigate the factors related to insulin resistance and islet β cell secretory function in subjects with normal glucose tolerance(NGT).Methods:Insulin resistance and islet β cell secretory function were estimated by Homeostasis Model Assessment in 2120 NGT subjects.Results:(1)ANOVA showed that there were significant differences in Homa-IR and Homa-β cell among different age groups(P<0.05).(2)t test indicated that there were significant differences in HOMA-IR and HOMA-β cell in overweight/obesity group

central obesity group

high TG group and hypertension group compared with their control groups respectively(P<0.01).(3)Stepwise regression revealed that the main factors influencing HOMA-IR and HOMA-β cell included age

BMI

waist circumference

TG and diastolic blood pressure.Conclusion:In NGT population

IR is aggravating with the age

BMI

waist circumference

TG and blood pressure;islet β cell secretory function is weakening with aging

while it is enhancing with BMI

waist circumference

TG and blood pressure to maintain normal glucose tolerance.

关键词

正常糖耐量胰岛素抵抗胰岛β细胞分泌功能

Keywords

Normal glucose toleranceinsulin resistanceIslet β cell secretory function

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The role of RNA m⁶A methylation in insulin resistance in adipocytes

Mediating role of TYG-BMI in vitamin D and nonalcoholic fatty liver disease

Association between glucose metabolism disorder and prevalence of thyroid nodule in the elderly in iodine-adequate area

Association of serum irisin and insulin resistant in female with polycystic ovary syndrome

Association between body mass index and the incidence of type 2 diabetes mellitus

Related Author

Ye Diwen

Zhang Bingyang

Zhang Dantong

Ma Wanshan

Lu Sumei

Sun Wenwen

Xing Yuling

Huo Lijing

Related Institution

Department of Laboratory Medicine，The First Affiliated Hospital of Shandong First Medical University/Shandong Provincial Qianfoshan Hospital，Shandong Provincial Medicine and Health Key Laboratory of Clinical Laboratory Diagnostics

Cheeloo College of Medicine，Shandong University

School of Medical Laboratory，Weifang Medical University

Graduate School，North China University of Science and Technology

Department of Endocrinology， Hebei General Hospital

⁰