Clinical significance of serum ferritin assay in hepatic injury

XIA Jirong

doi:10.13406/j.cnki.cyxb.2003.06.020

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Clinical significance of serum ferritin assay in hepatic injury

更新时间：2024-01-17

- Clinical significance of serum ferritin assay in hepatic injury
- Journal of Chongqing Medical University Issue 6, Pages: 751-753(2003)
- 作者机构：
  
  重庆医科大学临床学院检验科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.06.020
  CLC： R446.6
- Published：2003，
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[1]夏吉荣.血清铁蛋白测定在肝损伤中的临床意义[J].重庆医科大学学报,2003(06):751-753.

XIA Jirong. Clinical significance of serum ferritin assay in hepatic injury. [J]. Journal of Chongqing Medical University (6):751-753(2003)
[1]夏吉荣.血清铁蛋白测定在肝损伤中的临床意义[J].重庆医科大学学报,2003(06):751-753. DOI： 10.13406/j.cnki.cyxb.2003.06.020.

XIA Jirong. Clinical significance of serum ferritin assay in hepatic injury. [J]. Journal of Chongqing Medical University (6):751-753(2003) DOI： 10.13406/j.cnki.cyxb.2003.06.020.

摘要

目的 :探讨血清铁蛋白（SF）在肝损伤时的变化

将SF用于肝损伤评估的可能性。方法 :对 71例乙型病毒性肝炎（HB）、78例甲型病毒性肝炎（HA）

3例药物性肝炎（DIH）患者用ELISA法定量测定其血清铁蛋白

用化学法测定其谷丙转氨酶（ALT）、血清总胆红素（TB）。结果 :HA

HB及DIH的急性期SF和ALT均明显增高（P <0 .0 1）。HA恢复初期多数患者ALT恢复正常

SF虽然有下降但仍未正常

与对照组比较仍有显著性（P <0 .0 1）。ALT、TB正常的HB患者有SF增高（P <0 .0 5 ）

ALT、TB异常的HB患者SF明显增高（P <0 .0 1）

并与ALT和 /或TB呈正相关。DIH急性期SF极度增高。重症肝炎ALT下降时

有SF持续升高。结论 :血清铁蛋白检测是评价肝功能的又一实验室指标

其比ALT更能反映肝损害的实际情况。

Abstract

Objective:To study concentration change in serum ferritin(SF) in hepatic injury

and the possibility of using SF index to evaluate hepatic injury.Methods:The concentration of SF

and serum glutamic-pyruvic transaminase(ALT)

total bilirubin (TB) in 71 cases of viral hepatitis B(HB)

78 cases of viral hepatitis A(HA) and 3 cases of drug-induced hepatitis(DIH) were detected by ELISA and chemistry measurement method.Results:The levels of SF and ALT in HA

HB and DIH increased significantly compared with the control group (P<0.01).In the HA patients at early stage of recovery

ALT level decreased to normal

while SF level also decreased but not to normal

and there was still significant increase compared with the control group(P<0.01).The SF concentration increased (P<0.05) in the HB patients with normal ALT and TB levels and it significantly increased (P<0.01) in those HB patients with abnormal ALT and TB levels

the change in SF concentration was positively correlated with ALT and/or TB.The SF concentration increased greatly in the DIH patients at acute stage.When ALT level decreased the SF concentration continued to rise in the grave hepatitis A or B.Conclusion:SF assay was a new laboratory marker in liver function evaluation

and could better reflect the actual pathological changes than ALT.

关键词

血清铁蛋白肝损伤病毒性肝炎药物性肝炎

Keywords

Serum ferritinHepatic injuryviral hepatitisDrug-induced hepatitis

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