Relationship between serum uric acid level and coronary heart disease

LIU Jian; et al

doi:10.13406/j.cnki.cyxb.2003.06.017

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Relationship between serum uric acid level and coronary heart disease

更新时间：2024-01-17

- Relationship between serum uric acid level and coronary heart disease
- Journal of Chongqing Medical University Issue 6, Pages: 741-743(2003)
- 作者机构：
  
  1. 重庆医科大学临床学院心内科
  2. 重庆医科大学临床学院心内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.06.017
  CLC： R541.4
- Published：2003，
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[1]刘剑,雷寒,覃数,马康华.血尿酸水平与冠心病的关系[J].重庆医科大学学报,2003(06):741-743+747.

LIU Jian, et al. Relationship between serum uric acid level and coronary heart disease. [J]. Journal of Chongqing Medical University (6):741-743(2003)
[1]刘剑,雷寒,覃数,马康华.血尿酸水平与冠心病的关系[J].重庆医科大学学报,2003(06):741-743+747. DOI： 10.13406/j.cnki.cyxb.2003.06.017.

LIU Jian, et al. Relationship between serum uric acid level and coronary heart disease. [J]. Journal of Chongqing Medical University (6):741-743(2003) DOI： 10.13406/j.cnki.cyxb.2003.06.017.

摘要

目的 :研究血尿酸水平与冠心病的关系。方法 :2 12例住院病人

分为非冠心病组（91例）和冠心病组（12 1例） ;冠心病组又分为单支病变亚组（5 0例）、两支病变亚组（30例）和三支病变亚组（41例） ;比较在不同分组条件下各组间血尿酸水平的差别。多元逐步回归分析血尿酸水平与冠状动脉病变积分间的相关性

Logistic回归分析血尿酸水平与冠心病发病间的相关性。结果 :冠心病组血尿酸水平 [（378± 10 0 ） μmol/L]非常显著高于非冠心病组 [（345± 77） μmol/L]（P <0 .0 1） :单支病变亚组、两支病变亚组和三支病变亚组血尿酸水平分别为（348± 88） μmol/L、（397± 10 4 ） μmol/L和（40 7± 10 9） μmol/L

两支病变亚组和三支病变亚组均显著高于单支病变亚组（P <0 .0 5 ;P <0 .0 1） ;血尿酸水平与冠状动脉病变积分非常显著相关（P<0 .0 1） ;Logistic回归分析结果表明

调整年龄、性别、BMI、SBP、DBP、PP、TC、TG、HDL、LDL、ApoA1、ApoB、Lp（a）、Glu后

血尿酸水平与冠心病的发病间无显著相关性（P >0 .0 5 ）。结论 :血尿酸水平随冠心病人病情严重程度而增加

但不是冠心病的独立危险因素。

Abstract

Objective:To study the relationship between serum uric acid level and coronary heart disease.Methods:212 patients in hospital were divided into two groups of non-coronary heart disease (91 cases) and coronary heart disease (121 cases).The group of coronary heart disease was divided into three subgroups of single-branch

double-branch and three-branch according to the scope of pathological changes.The serum uric acid levels in different groups were compared.The correlation between serum uric acid level and coronary artery lesion was analysed using univariate stepwise regression model.The logistic regression analysis was used to investigate the association of serum uric acid level with the incidence of coronary heart disease.Results:The serum uric acid level in coronary heart disease group[(378±100)μmol/L]was significantly higher than that in non-coronary heart disease group[(345±77)μmol/L](P<0.01).The serum uric acid levels of single-branch subgroup

double-branch subgroup and three-branch subgroup were (348±88)μmol/L

(397+104)μmol/L and (407+109)μmol/L respectively.The serum uric acid levels in double-branch subgroup and three-branch subgroup were obviously higher than that in single-branch subgroup(P<0.05

P<0.01).There was pronounced positive correlation between serum uric acid level and coronary artery lesion(P<0.01).The logistic regression analysis indicated the serum uric acid level was not related to the incidence of coronary heart disease after adjusting age

sex

BMI

SBP

DBP

HDL

LDL

ApoA 1

ApoB

Lp(a) and Glu(P>0.05).Conclusion:The serum uric acid level increases along with the severity of coronary heart disease

but it is not an independent risk factor for coronary heart disease.

关键词

血尿酸冠心病相关性

Keywords

Serum uric acidcoronary heart diseasecorrelation

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马康华

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陈运贞

Zhang Yulian

Deng Wei

Wang Yunhui

Related Institution

Cardiology Division,College of Clinical Medicine,Chongqing Medical University

Department of General Medicine，The Second Affiliated Hospital of Chongqing Medical University

Department of Urology，Yongchuan Hospital Affiliated to Chongqing Medical University

Department of Neurology，The First Affiliated Hospital of Chongqing Medical University

Department of Ultrasound，Yichang Central People's Hospital，The First College of Clinical Medical Science，China Three Gorges University

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