Relationship between assays of TNF-α,ICAM-1 and deep venous thromboses in patients with hip or pelvis fracture

CHEN Shirong; et al

doi:10.13406/j.cnki.cyxb.2003.06.016

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Relationship between assays of TNF-α,ICAM-1 and deep venous thromboses in patients with hip or pelvis fracture

更新时间：2024-01-17

- Relationship between assays of TNF-α,ICAM-1 and deep venous thromboses in patients with hip or pelvis fracture
- Journal of Chongqing Medical University Issue 6, Pages: 738-740(2003)
- 作者机构：
  
  1. 重庆医科大学第二临床学院骨科
  2. 山东省立医院骨科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.06.016
  CLC： R683
- Published：2003，
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[1]陈世荣,黄朝梁,邓忠良,张进禄.髋部和骨盆骨折患者肿瘤坏死因子-α、粘附分子-1的测定及其与静脉血栓形成的关系[J].重庆医科大学学报,2003(06):738-740.

CHEN Shirong, et al. Relationship between assays of TNF-α,ICAM-1 and deep venous thromboses in patients with hip or pelvis fracture. [J]. Journal of Chongqing Medical University (6):738-740(2003)
[1]陈世荣,黄朝梁,邓忠良,张进禄.髋部和骨盆骨折患者肿瘤坏死因子-α、粘附分子-1的测定及其与静脉血栓形成的关系[J].重庆医科大学学报,2003(06):738-740. DOI： 10.13406/j.cnki.cyxb.2003.06.016.

CHEN Shirong, et al. Relationship between assays of TNF-α,ICAM-1 and deep venous thromboses in patients with hip or pelvis fracture. [J]. Journal of Chongqing Medical University (6):738-740(2003) DOI： 10.13406/j.cnki.cyxb.2003.06.016.

摘要

目的 :探讨髋部和骨盆骨折患者血清中的肿瘤坏死因子 -α（TNF -α）、粘附分子 - 1（ICAM - 1）的测定值变化与深静脉血栓形成的关系及其临床意义。方法 :本科髋部及骨盆骨折患者

根据静脉造影分为血栓组和无血栓组

于术前、术后 1天、术后 3天、术后 7天、术后 14天抽清晨肘静脉空腹血

测定血清TNF -α、ICAM - 1的含量。结果 :血栓发生组和无血栓发生组TNF -α、ICAM - 1浓度较正常对照组明显升高（P <0 .0 1）。结论 :TNF -α、ICAM - 1在严重损伤患者血清中明显升高

和静脉血栓形成有关。

Abstract

Objective:The patients undergoing operation for the fracture of hip or/and pelvis are at risks for venous thromboembolic complication.We measured the level of tumor necrosis factor-alpha(TNF-α) and intercellular adhesion molecule-1(ICAM-1) to evaluate the relation between cytokine and deep venous thromboses(DVT).Methods:28 patients of fracture of hip or/and pelvis were divided into two groups according to venography.The levels of ICAM-1 were tested with enzyme-linked immunosorbent assay(ELISA)

while TNF-α were tested with radioimmunoassay at the first day after injury

and 1st

3rd

7th

12th day of postoperative period.Results:We found a marked increase of TNF-α and ICAM-1 in all the patients

and there was significant difference between the patients and normal controls (P<0.01).The level of ICAM-1 in the patients with DVT was significantly higher than those without DVT(P<0.05).Conclusion:These data suggest that TNF-α and ICAM-1 may be involved in the development of thromboembolic disease.

关键词

肿瘤坏死因子-α粘附分子-1:血管内皮静脉血栓

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