Effect of magnesium sulfate on excitatory amino acids following traumatic brain injury in rats

SHI Quanhong; et al

doi:10.13406/j.cnki.cyxb.2003.06.014

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Effect of magnesium sulfate on excitatory amino acids following traumatic brain injury in rats

更新时间：2024-01-17

- Effect of magnesium sulfate on excitatory amino acids following traumatic brain injury in rats
- Journal of Chongqing Medical University Issue 6, Pages: 732-734(2003)
- 作者机构：
  
  1. 重庆医科大学临床学院神经外科
  2. 重庆医科大学临床学院神经外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.06.014
  CLC： R651.1
- Published：2003，
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[1]石全红,支兴刚,唐文渊,何朝晖.硫酸镁对大鼠创伤性脑损伤兴奋性氨基酸的影响[J].重庆医科大学学报,2003(06):732-734.

SHI Quanhong, et al. Effect of magnesium sulfate on excitatory amino acids following traumatic brain injury in rats. [J]. Journal of Chongqing Medical University (6):732-734(2003)
[1]石全红,支兴刚,唐文渊,何朝晖.硫酸镁对大鼠创伤性脑损伤兴奋性氨基酸的影响[J].重庆医科大学学报,2003(06):732-734. DOI： 10.13406/j.cnki.cyxb.2003.06.014.

SHI Quanhong, et al. Effect of magnesium sulfate on excitatory amino acids following traumatic brain injury in rats. [J]. Journal of Chongqing Medical University (6):732-734(2003) DOI： 10.13406/j.cnki.cyxb.2003.06.014.

摘要

目的 :观察兴奋性氨基酸（EAA）在创伤性颅脑损伤（TBI）后的变化

探讨硫酸镁对EAA的调节作用。方法 :采用自由落体脑损伤模型

应用氨基酸微量分析仪检测正常组、假损伤组、损伤及损伤给药组脑脊液中谷氨酸（Glu）和天门冬氨酸（Asp）。结果 :1.伤后 2hEAA升高最明显（P <0 .0 5 ）

随后逐渐降低

12h与正常组、假损伤组比较无显著性差异（P >0 .0 5 ）。2 .硫酸镁对伤后 2hEAA的抑制作用最显著（P <0 .0 5 ）

在 12h、2 4h、4 8h、72h对EAA抑制作用无显著性（P >0 .0 5 ）。结论 :TBI早期EAA大量释放。镁剂可抑制早期EAA释放

达到脑保护作用。

Abstract

Objective:To investigate the level of excitatory amino acids in the cerebrospinal fluid and the effect of magnesium sulfate on the excitatory amino acids following traumatic brain injury. Methods:The Feeney′s model of the excitatory amino acids in the cerebrospinal fluid (glutamate and aspartate) were measured by amino acid analysis from rats in different time. Results:1. The glutamate and aspartate in the cerebrospinal fluid increased largely 2 hours after traumatic brain injury(P<0.05)

and then gradually decreased. Compared with sham control group

the concentration of excitatory amino acids at 12h after injury had no significant difference ( P>0.05).2.Magnesium inhibited strongly the releasing of the excitatory amino acids at 2h and 8h after the traumatic brain injury(P<0.05)

and it had no effect on the releasing of the excitatory amino acids at 12h

24h

48h

72h after traumatic brain injury(P>0.05).Conclusion:Plenty releasing of excitatory amino acid may play an important role at the phase of posttraumatic neuronal injury.Magnesium sulfate can inhibit early releasing of excitatory amino acids.Administering magnesium sulfate may be the optimal choice for treating traumatic brain injury.

关键词

创伤性脑损伤硫酸镁兴奋性氨基酸谷氨酸天门冬氨酸

Keywords

traumatic brain injuryMagnesium sulfateExcitatory amino acidsglutamateAspartate

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Related Institution

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重庆医科大学临床学院神外科

Department of Neurosurgery,the Children’s Hospital,Chongqing Medical University

Department of Neurology,the Children’s Hospital,Chongqing MedicaI University

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