Study on the expression of PPARs and NFκB in endothciial cells of hyperlipidemic rats

HUANG Ying; et al

doi:10.13406/j.cnki.cyxb.2003.06.006

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Study on the expression of PPARs and NFκB in endothciial cells of hyperlipidemic rats

更新时间：2024-01-17

- Study on the expression of PPARs and NFκB in endothciial cells of hyperlipidemic rats
- Journal of Chongqing Medical University Issue 6, Pages: 701-703(2003)
- 作者机构：
  
  1. 重庆医科大学临床学院心内科
  2. 重庆医科大学基础医学院组胚教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.06.006
  CLC： R589.2
- Published：2003，
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[1]黄颖,陈运贞,吴宏,姜蓉,李静.PPARs和NFκB在高脂血症大鼠内皮细胞中表达的研究[J].重庆医科大学学报,2003(06):701-703+734.

HUANG Ying, et al. Study on the expression of PPARs and NFκB in endothciial cells of hyperlipidemic rats. [J]. Journal of Chongqing Medical University (6):701-703(2003)
[1]黄颖,陈运贞,吴宏,姜蓉,李静.PPARs和NFκB在高脂血症大鼠内皮细胞中表达的研究[J].重庆医科大学学报,2003(06):701-703+734. DOI： 10.13406/j.cnki.cyxb.2003.06.006.

HUANG Ying, et al. Study on the expression of PPARs and NFκB in endothciial cells of hyperlipidemic rats. [J]. Journal of Chongqing Medical University (6):701-703(2003) DOI： 10.13406/j.cnki.cyxb.2003.06.006.

摘要

目的 :探讨核转录因子PPARα、PPARγ和NFκB在正常及高脂血症大鼠主动脉内皮细胞中表达的变化以及fibrate干预后炎性因子IL - 6的变化。方法 :取正常及高脂血症大鼠模型主动脉冰冻切片行免疫组化分析PPARα、PPARγ、NFκB和IL - 6的表达

PPARs的人工合成配体Gemfibrate和Bezafibrate干预后的变化及其关系。结果 :正常大鼠主动脉上有PPARα、PPARγ、NFκB和IL - 6的弱表达。高脂血症时

主动脉内皮细胞层PPARα、PPARγ、NFκB、IL - 6的表达增强

其OD值较正常大鼠显著增加（P <0 .0 5 ）

NFκB的活化明显。Fibrates药物干预后

血脂下降（除HDL）

PPARα、PPARγ进一步活化

IL - 6的表达减弱

对NFκB的表达无明显影响。结论 :核转录因子PPARs和NFκB在高脂血症人鼠内皮细胞中均显著增加。Fi brates类药物可通过活化相应受体PPARs部分抑制炎性因子的分泌。

Abstract

Objective: To investigate the expression of PPARα

PPARγ and NFκB in the aortic endothelial cells of the normal and hyperlipidemic rats and the change of IL-6 with the treatment of fibrates in vivo.Methods:The hyperlipidemic rat was established by feeding the high cholesterol food.The expressions of PPARα

PPARγ

NFκB and IL-6 in endothelial cells located in the aorta were presented by immunohistochemistry.The alteration among the PPARα

PPARγ and IL-6 in the hyperlipidemic rat with the treatment of gemfibrate and bezafibrate was observed.Results:There was a weak expression of PPARα

PPARγ

NFκB and IL-6 in the normal rat aorta endothelial cells

which were all enhanced in the hyperlipidemic rat.NFκB was drastically presented.After the treatment of gemfibrate and bezafibrate the expression of PPARα increased

while that of IL-6 decreased relatively

but NFκB expression was not directly influenced.Conclusion:The expressions of PPARs and NFκB increased in hyperlipidemic rats.Fibrates may relieve the secretion of inflammation factors in vivo to some degree through the activation of PPARs.

关键词

PPARsNFκB动脉粥样硬化

Keywords

PPARsNFκBatherosclerosis

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重庆医科大学临床学院心内科

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Department of Cardiology,the Second Affiliated Hospital,Chongqing Medical University

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