The safety evaluation of high intensity focused ultrasound for the treatment of implanted rabbit breast tumor

WU Chuanxin; et al

doi:10.13406/j.cnki.cyxb.2003.06.002

您当前的位置：

首页 >

文章列表页 >

The safety evaluation of high intensity focused ultrasound for the treatment of implanted rabbit breast tumor

更新时间：2024-01-17

- The safety evaluation of high intensity focused ultrasound for the treatment of implanted rabbit breast tumor
- Journal of Chongqing Medical University Issue 6, Pages: 685-687(2003)
- 作者机构：
  
  1. 重庆医科大学第二临床学院外科
  2. 重庆医科大学医学超声工程研究所,重庆,400010
  3. ,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.06.002
  CLC： R737.9
- Published：2003，
扫描看全文
[1]吴传新,刘长安,伍烽,白晋,陈文直,邹建中,乔天愚,王智彪.高强度聚焦超声治疗兔移植性乳腺肿瘤的安全性评价[J].重庆医科大学学报,2003(06):685-687+700.

WU Chuanxin, et al. The safety evaluation of high intensity focused ultrasound for the treatment of implanted rabbit breast tumor. [J]. Journal of Chongqing Medical University (6):685-687(2003)
[1]吴传新,刘长安,伍烽,白晋,陈文直,邹建中,乔天愚,王智彪.高强度聚焦超声治疗兔移植性乳腺肿瘤的安全性评价[J].重庆医科大学学报,2003(06):685-687+700. DOI： 10.13406/j.cnki.cyxb.2003.06.002.

WU Chuanxin, et al. The safety evaluation of high intensity focused ultrasound for the treatment of implanted rabbit breast tumor. [J]. Journal of Chongqing Medical University (6):685-687(2003) DOI： 10.13406/j.cnki.cyxb.2003.06.002.

摘要

目的 :评价高强度聚焦超声（HighIntensityFocusedUltrasound

HIFU）治疗兔乳腺移植性肿瘤的安全性。方法 :4 0只兔乳腺移植性肿瘤于肿瘤移植后 11天随机分为治疗组 2 0只

手术组 10只

对照组 10只。治疗组接受HIFU覆盖治疗

手术组接受常规手术切除局部肿瘤

对照组接受假照治疗。采集辐照前后声像图进行对比性观察

于HIFU辐照后即刻切取肿瘤作肉眼观察

观察肿瘤的转移情况。HIFU辐照前后查肝功、生化及肾功

观察其变化。结果 :HIFU辐照前肿瘤声像图呈低回声团块

辐照后肿瘤声像图呈明显强回声。HIFU辐照前肿瘤切面呈粉红色

辐照后肿瘤呈白色凝固性损伤灶 ;治疗组和手术组的肿瘤转移率分别为 2 0 %和 30 %

无显著性差异（P >0 .0 5 ）

均明显低于对照组（10 0 %

P <0 .0 5 ）。HIFU辐照后治疗组动物的肝功、血生化及肾功与辐照前相比

以及手术组和对照组比较

差异无显著性（P >0 .0 5 ）。结论 :在B超实时监控下

HIFU准确有效地杀灭乳腺肿瘤

不增加肿瘤转移的危险性

对动物的肝功、血生化及肾功无影响。因此

HIFU治疗系统治疗是安全的。

Abstract

Objective:To evaluate the safety of high intensity focused ultrasound(HIFU) for the treatment of implanted rabbit breast tumor.Methods:Forty New England rabbits were randomly divided into the following groups:HIFU treatment group(20)

surgery group(10) and control group(10).HIFU ablation was performed at focal peak intensity 11500W/cm with a frequency of 1.6MHz in HIFU group.In surgery group all animals underwent lumpectomy.The animals in control group underwent pseudo-irradiation.The sonograms of target tumor were assessed before and immediately after HIFU ablation.The treated tumor was removed immediately after HIFU

and the lesion was measured by gross examination.Routine serum chemistry examination including hepatic

renal function tests

and serum electrolytes in all animals were performed before and at 1st

3rd

5th and 7th days after treatment.Also tumor metastases were observed after treatment.Results:The gray-scale of target tumors on ultrasound image was low before HIFU and increased immediately after HIFU irradiation.The hyperechoic location was the same as the lesion observed by gross observation.The necrotic lesion completely covered the tumor.No significant differences were observed in hepatic

renal function tests

and serum electrolytes before and after therapy in HIFU group.And these indices were not significantly different in HIFU treatment group

surgery group and control group

respectively.The metastatic rates of HIFU treatment group and surgery group were 20% and 30% respectively.They were significantly different from that of control group(100%

P<0.05).Conclusion:HIFU could precisely and effectively destroy the implanted rabbit breast tumor with guidance of ultrasound imaging.Because it does not increase the metastatic rate of tumor and affect the function of liver and kidney of animals

HIFU is safe for the treatment of breast carcinoma.

关键词

高强度聚焦超声High乳腺癌VX2肿瘤治疗手术

Keywords

High intensity focused ultrasound(HIFU)Breast tumorVX 2 carcinomatreatmentsurgery

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Research progress in the diagnosis and treatment of non-eosinophilic asthma

Clinical features and treatment outcome of scrotal abscess: an analysis of 24 cases

Diagnosis and treatment strategies for retroperitoneal vascular leiomyosarcoma

Feasibility and safety of hysteroscopic tissue removal system in treatment of interstitial ectopic pregnancy

Advances in clinical management of thyroid cancer in children and adolescents

Related Author

Zhang Xinyue

Shao Zijian

Lian Kang

Wu Demei

Yuan Bin

Wu Fang

Tang Lanfang

Xie Xiaodu

Related Institution

Department of Traditional Chinese Medicine，Children’s Hospital，Zhejiang University School of Medicine/ National Clinical Research Center for Child Health

Department of Pediatrics，The Affiliated Hospital of Nanjing University of Chinese Medicine，The First Clinical Medical College of Nanjing University of Chinese Medicine

Department of Respiratory Medicine，Children’s Hospital，Zhejiang University School of Medicine/ National Clinical Research Center for Child Health

Department of Urology，The Second Affiliated Hospital of Chongqing Medical University, The Second Affiliated Hospital of Chongqing Medical University

Department of Anesthesiology, The Second Affiliated Hospital of Chongqing Medical University

⁰