Radiotherapy for unresectable advanced pancreatic cancer

DAI Xiaobo; et al

doi:10.13406/j.cnki.cyxb.2003.05.034

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Radiotherapy for unresectable advanced pancreatic cancer

更新时间：2024-01-17

- Radiotherapy for unresectable advanced pancreatic cancer
- Journal of Chongqing Medical University Issue 5, Pages: 656-657(2003)
- 作者机构：
  
  1. 重庆医科大学临床学院放疗科
  2. 重庆医科大学临床学院放疗科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.05.034
  CLC： R735.9
- Published：2003，
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[1]戴晓波,陈晓品,陈绪元,张玲,赵斌,吴永忠,张菊,张涛.晚期胰腺癌放射治疗探讨[J].重庆医科大学学报,2003(05):656-657+659.

DAI Xiaobo, et al. Radiotherapy for unresectable advanced pancreatic cancer. [J]. Journal of Chongqing Medical University (5):656-657(2003)
[1]戴晓波,陈晓品,陈绪元,张玲,赵斌,吴永忠,张菊,张涛.晚期胰腺癌放射治疗探讨[J].重庆医科大学学报,2003(05):656-657+659. DOI： 10.13406/j.cnki.cyxb.2003.05.034.

DAI Xiaobo, et al. Radiotherapy for unresectable advanced pancreatic cancer. [J]. Journal of Chongqing Medical University (5):656-657(2003) DOI： 10.13406/j.cnki.cyxb.2003.05.034.

摘要

目的 :探讨不能手术切除的晚期胰腺癌放射治疗的疗效及价值。方法 :1996年 3月至 2 0 0 1年 12月我科共收治 16例不能切除的晚期胰腺癌患者行放射治疗。按TNM分期

Ⅱ期 5例

Ⅲ期 6例

Ⅳ期 5例。KPS评分 30～ 70分。采用常规分割（1.8～ 2 .0Gy/次

每周 5次） 8例

非常规分割（1.2～ 1.8Gy/次

每日 2～ 3次） 8例。放射治疗剂量 <4 0Gy3例

5 0～6 0Gy4例

6 0～ 70Gy6例

>70Gy3例。结果 :放疗止痛有效率 85 .7%

全组中位生存期 9.2个月（3～ 30月）

1年生存率 31.2 5 %。KPS评分及TNM分期影响生存

KPS6 0～ 70分组生存期明显长于KPS 30～ 5 0分组（P <0 .0 1）

Ⅱ、Ⅲ期患者生存期明显长于Ⅳ期（P <0 .0 1）。结论 :对不能切除的局部晚期胰腺癌采用放射治疗可有效缓解症状

改善生存质量

适当延长生存期。

Abstract

Objective:To study the treatment result of the unresectable advanced pancreatic cancer by radiotherapy. Methods: A total of 16 patients with unresectable advanced pancreatic cancer were treated by radiotherapy from March 1996 to December 2001. According to TNM staging system

there are 5 patients in stage II

6 in stage Ⅲ and 5 in stage Ⅳ. Karnofsky score were ranged from 30～70. Eight patients were treated by the conventional fractionation (1.8～2.0 cGy/f

5f/w)

and eight patients treated by non-conventional fractionation(1.2～1.8Gy/f

2～3f/d).The radiation dose was<40Gy for 3 cases

50～60Gy for 4 cases

61～70Gy for 6 cases

>70Gy for 3 cases. Results:The remission rate was 85.7 percent. The median survival course was 9.2 months(3～30months). 1-year survival rate was 31.25 percent. The pretreatment performance status and TNM stage were important prognostic factors. Both groups of Karnofsky score 60～70 and stageⅡ

Ⅲ showed a highly significantsurvival improvement when compared with groups of Karnofsky score 30～50and stage IV ( P <0.01). Conclusion:Radiotherapy is able to relieve symptoms

prolong survival time and improve life quality for patients with unresectable advanced cancer of pancreas.

关键词

晚期胰腺癌放射治疗预后因素

Keywords

Advanced pancreatic cancerradiotherapyprognostic factors

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