Clinical  significance and expression of Ki-67 in laryngeal carcinoma

SUN Yucai; et al

doi:10.13406/j.cnki.cyxb.2003.05.006

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Clinical significance and expression of Ki-67 in laryngeal carcinoma

更新时间：2024-01-17

- Clinical significance and expression of Ki-67 in laryngeal carcinoma
- Journal of Chongqing Medical University Issue 5, Pages: 573-575(2003)
- 作者机构：
  
  1. 重庆医科大学临床学院耳鼻喉科
  2. 重庆医科大学临床学院耳鼻喉科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.05.006
  CLC： R739.62
- Published：2003，
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[1]孙余才,胡国华,朱江.细胞增殖抗原Ki-67在喉癌中的表达及临床意义[J].重庆医科大学学报,2003(05):573-575+579.

SUN Yucai, et al. Clinical significance and expression of Ki-67 in laryngeal carcinoma. [J]. Journal of Chongqing Medical University (5):573-575(2003)
[1]孙余才,胡国华,朱江.细胞增殖抗原Ki-67在喉癌中的表达及临床意义[J].重庆医科大学学报,2003(05):573-575+579. DOI： 10.13406/j.cnki.cyxb.2003.05.006.

SUN Yucai, et al. Clinical significance and expression of Ki-67 in laryngeal carcinoma. [J]. Journal of Chongqing Medical University (5):573-575(2003) DOI： 10.13406/j.cnki.cyxb.2003.05.006.

摘要

目的 :探讨细胞增殖抗原Ki- 6 7在喉癌组织中的表达及临床意义。方法 :采用免疫组织化学S -P法检测 4 1例喉癌组织中Ki- 6 7的表达

并与 12例癌旁正常组织作对照

进行分析比较。结果 :4 1例喉癌组织中Ki - 6 7的阳性表达率为5 3.6 %

12例癌旁正常组织阳性表达率为 16 .7%

二者具有显著性差异（P <0 .0 5 ）。Ki- 6 7的阳性表达率与喉癌病人的不同性别、年龄、病程、肿瘤部位和TNM分期无关（P >0 .0 5 ）

但与吸烟、饮酒、淋巴结有无转移以及喉癌组织的病理分级之间具有显著性差异（P <0 .0 5

P <0 .0 1）。结论 :Ki- 6 7在喉癌的发生发展中起一定的作用

可作为判断喉癌恶性程度和预后的重要参考指标。

Abstract

Objective:To determine clinical significance and expression of cellular proliferative antigen Ki-67 in laryngeal carcinoma tissues.Methods:Ki-67 expressions in 41 cases of laryngeal carcinoma tissues were detected by immunohistochemical S-P method;12 cases of pericarcinoma tissues were used as control and comparison.Results:The positive expression rate of Ki-67 was 53.6% in 41 cases of laryngeal carcinoma tissues and 16.7% in 12 cases of pericarcinoma tissues

which showed significant difference ( P <0.05).There was no significant difference in sex

age

course

tumor site and TNM stage.The levels of Ki-67 expression were significantly higher in the groups with smoking

drinking habits and lymph node metastasis than in those without ( P <0.05).The positive expression rate of Ki-67 showed significant difference among pathological stages of laryngeal carcinoma tissues ( P <0.01).Conclusion:The results suggest that the Ki-67 might play an important role in the development and progression of laryngeal carcinoma and should be used as an important reference marker of malignant degree and prognosis of laryngeal carcinoma.

关键词

喉癌Ki-67免疫组织化学

Keywords

laryngeal carcinomaKi-67immunohistochemistry

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Related Institution

Department of Otorhinolaryngology,College of Clinical Medicine,Chongqing Medical University

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重庆医科大学临床学院耳鼻咽喉科

Department of Otolaryngology,College of Clinical Medicine,Chongqing Medical University

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