Dose effect on ablation of human uterine myoma in vitro with HIFU scanning

CHANG Shufang; et al

doi:10.13406/j.cnki.cyxb.2003.05.002

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Dose effect on ablation of human uterine myoma in vitro with HIFU scanning

更新时间：2024-01-17

- Dose effect on ablation of human uterine myoma in vitro with HIFU scanning
- Journal of Chongqing Medical University Issue 5, Pages: 562-563(2003)
- 作者机构：
  
  1. 重庆医科大学第二临床学院妇产科
  2. 重庆医科大学医学超声工程研究所,重庆,400010
  3. ,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.05.002
  CLC： R737.33
- Published：2003，
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[1]常淑芳,顾美礼,伍烽,王智彪.高强度聚焦超声扫描损伤离体人子宫肌瘤的能效关系研究[J].重庆医科大学学报,2003(05):562-563+570.

CHANG Shufang, et al. Dose effect on ablation of human uterine myoma in vitro with HIFU scanning. [J]. Journal of Chongqing Medical University (5):562-563(2003)
[1]常淑芳,顾美礼,伍烽,王智彪.高强度聚焦超声扫描损伤离体人子宫肌瘤的能效关系研究[J].重庆医科大学学报,2003(05):562-563+570. DOI： 10.13406/j.cnki.cyxb.2003.05.002.

CHANG Shufang, et al. Dose effect on ablation of human uterine myoma in vitro with HIFU scanning. [J]. Journal of Chongqing Medical University (5):562-563(2003) DOI： 10.13406/j.cnki.cyxb.2003.05.002.

摘要

目的 :通过研究高强度聚焦超声（highintensityfocusedultrasound

HIFU）扫描损伤离体人子宫肌瘤的能效关系

寻找HIFU扫描损伤子宫肌瘤的适宜参数。方法 :不同声强及辐照时间的HIFU（频率 0 .8MHz

焦距 117mm

声强 0～ 85 87.6W /cm2 ）在相同的扫描线长下对同一焦点深度的离体人子宫肌瘤组织进行扫描损伤

记录不同声强造成组织损伤的阈扫描时间并计算其损伤灶体积及能效因子。结果 :在相同的声强下

损伤体积随辐照时间的延长而增加

阈扫描时间随声强的增加而减少

能效因子随声强及扫描时间不同而发生变化

随着声强的增大

最佳能效关系点出现后移

焦点声强为 5 76 2 .7W /cm2 时其阈扫描时间（4 5s）为出现最佳能效因子所需的扫描时间。结论 :HIFU以 15mm线长进行扫描损伤子宫肌瘤时

焦点声强5 76 2 .7W /cm2 、扫描时间 4 5s是适宜的治疗参数。

Abstract

Objective:To explore the dose-effect on ablation of human uterine myoma with HIFU scanning and find a suitable exposure parameters for HIFU ablation of uterine myoma in vitro.Methods:An extracorporeal HIFU transducer with a frequency of 0.8 MHz

intensity 0～8587.6W/cm 2 and focal length of 117mm was used.Thirty-one human uterine myoma specimens were sonicated by ultrasound with different intensity and exposure time.The threshold time and lesion size were determined and the energy efficiency factor was calculated.Results:It was found that under the same intensity

the lesion size increased with exposure time

while the threshold time decreased with the intensity.The energy efficiency factor was related to intensity and exposure time

and it was optimal under the threshold time (45s) when focal intensity was 5762.7W/cm 2.Conclusion:While using the scanning line of 15mm

the suitable exposure parameters for HIFU ablation of uterine myoma was 45 seconds for scanning lesion with focal intensity of 5762.7W/cm 2

关键词

高强度超声子宫肌瘤能效因子

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