To investigate the relationship between Helicobacter pylori and  reflux esophagitis

ZHANG Junwen; et al

doi:10.13406/j.cnki.cyxb.2003.04.038

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To investigate the relationship between Helicobacter pylori and reflux esophagitis

更新时间：2024-01-17

- To investigate the relationship between Helicobacter pylori and reflux esophagitis
- Journal of Chongqing Medical University Issue 4, Pages: 532-534(2003)
- 作者机构：
  
  1. 重庆医科大学临床学院消化内科
  2. 重庆医科大学临床学院消化内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.04.038
  CLC： R571
- Published：2003，
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[1]张俊文,王丕龙.反流性食管炎与幽门螺杆菌感染关系的探讨[J].重庆医科大学学报,2003(04):532-534.

ZHANG Junwen, et al. To investigate the relationship between Helicobacter pylori and reflux esophagitis. [J]. Journal of Chongqing Medical University (4):532-534(2003)
[1]张俊文,王丕龙.反流性食管炎与幽门螺杆菌感染关系的探讨[J].重庆医科大学学报,2003(04):532-534. DOI： 10.13406/j.cnki.cyxb.2003.04.038.

ZHANG Junwen, et al. To investigate the relationship between Helicobacter pylori and reflux esophagitis. [J]. Journal of Chongqing Medical University (4):532-534(2003) DOI： 10.13406/j.cnki.cyxb.2003.04.038.

摘要

目的 :探讨反流性食管炎与幽门螺杆菌感染的关系。方法 :选取胃镜诊断为食管炎的病人 14 88例

根据食管炎的Tytagat内镜分级将其分为Ⅰ～Ⅴ五级 ;取胃黏膜组织

用HP检测试纸行快速尿素酶测定

对照组慢性胃炎的病人 16 0 0例 ;消化性溃疡的病人 16 0 0例。结果 :反流性食管炎组幽门螺杆菌感染率 6 3.0 4 %。胃炎组感染率 6 5 .15 %

同反流性食管炎组相比无差异（P >0 .0 5 ）。溃疡组感染率为 74 .5 0 % （P <0 .0 1）。Ⅰ～Ⅴ级反流性食管炎中反流性食管炎愈重HP检出率愈低（P <0 .0 1） ;反流性食管炎严重程度同HP感染严重程度成负相关（P <0 .0 1）。结论 :1)幽门螺杆菌感染同反流性食管炎发病的关系尚有争议。 2 )幽门螺杆菌在反流性食管炎的发病过程中起着保护的作用。 3)反流性食管炎患者抗幽门螺杆菌的治疗应在反流性食管炎经治疗后症状消失而药物未停的情况下

谨慎进行。

Abstract

Objective:To investigate the relationship between Helicobacter pylori(HP) and reflux esophagitis(RE). Methods: 1488 patients with esophagitis were diagnosed by gastroscope

and all of the patients were divided into five groups according to Tytagat. Biopsy specimens of each gastric mucosa were examined by rapid urease test assay.1600 patients with chronic gastritis and duodenal ulcer were also examined by rapid urease test assay. Results: The positive rates of Helicobacter pylori in reflux esophagitis

chronic gastritis and duodenal ulcer were63.04%

65.15% and 74.50%( P >0.05 and P <0.01) respectively. There was a negative correlation

the lower the positive rates

the heavier the reflux esophagitis ( P <0.01)

between the several levels of Helicobacter pylori and reflux esophagitis ( P <0.01) .Conclusion:1) There exists a dispute between Helicobacter pylori and episode procedure of reflux esophagitis. 2)Helicobacter pylori plays a protective role in episode procedure of reflux esophagitis.3)The eradication therapy for Helicobacter pylori should be taken more cautiously in the treatment of reflux esophagitis with continuing drug administration till its symptoms disappear.

关键词

反流性食管炎幽门螺杆菌胃镜快速尿素酶测定

Keywords

Helicobacter pyloriReflux esophagitisgastroscopeRapid urease test assay

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Related Institution

Department of Gastroenterology, College of Clinical Medicine, Chongqing Medical University

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