A study on collagen constitute and formation of hypertrophic scar  in different age periods

QIU Lin; et al

doi:10.13406/j.cnki.cyxb.2003.04.034

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A study on collagen constitute and formation of hypertrophic scar in different age periods

更新时间：2024-01-17

- A study on collagen constitute and formation of hypertrophic scar in different age periods
- Journal of Chongqing Medical University Issue 4, Pages: 521-524(2003)
- 作者机构：
  
  1. 重庆医科大学儿科学院烧伤整形科
  2. 重庆医科大学儿科学院烧伤整形科,重庆,400014
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.04.034
  CLC： R622
- Published：2003，
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[1]邱林,金先庆,向代理,傅跃先,田晓菲.胶原构成与不同年龄增生性瘢痕形成的研究[J].重庆医科大学学报,2003(04):521-524.

QIU Lin, et al. A study on collagen constitute and formation of hypertrophic scar in different age periods. [J]. Journal of Chongqing Medical University (4):521-524(2003)
[1]邱林,金先庆,向代理,傅跃先,田晓菲.胶原构成与不同年龄增生性瘢痕形成的研究[J].重庆医科大学学报,2003(04):521-524. DOI： 10.13406/j.cnki.cyxb.2003.04.034.

QIU Lin, et al. A study on collagen constitute and formation of hypertrophic scar in different age periods. [J]. Journal of Chongqing Medical University (4):521-524(2003) DOI： 10.13406/j.cnki.cyxb.2003.04.034.

摘要

目的 :通过观察不同年龄正常皮肤（NS）、增生性瘢痕（HTS）胶原构成、比例

初步探讨各年龄阶段HTS形成的可能机理及条件。方法 :采用SABC免疫组织化学方法观察胎儿、1～ 19岁（儿童青少年组）、2 0～ 5 0岁（成年组）、>6 0岁（老年组）正常皮肤和 1～ 19岁、2 0～ 5 0岁HTS中Ⅰ、Ⅲ型胶原含量和比例。结果 :①胎儿组Ⅲ型胶原含量高于Ⅰ型胶原

其余组为Ⅰ型胶原高于Ⅲ型胶原 ;正常皮肤Ⅰ /Ⅲ型胶原比例随年龄增加呈上升趋势。HTS组织的Ⅰ /Ⅲ型胶原比例明显高于正常皮肤（NS）

1～ 19岁HTS组Ⅰ /Ⅲ型胶原比例较 2 0～ 5 0岁HTS组增高

平均为 6 .4 8

3.76 ;HTS组各病程之间Ⅰ /Ⅲ型胶原比例无差异。结论 :Ⅰ、Ⅲ型胶原的含量和比例决定着皮肤的正常结构

Ⅰ

Ⅲ型胶原比例的失调与不同年龄HTS的形成有着密切关系。

Abstract

Objective:To investigate the mechanism of hypertrophic scar formation in different age periods.Methods:The expression of type I and type Ⅲ collagen of hypertrophic scar in different age periods was measured with immunohistochemistry which was divided into two groups 1～19 years old and 20～50 years old

and the same measure was adopted in normal skin divided into four groups-fetal

1～19

20～50

and more than 60 years old .The quantities of type I and type Ⅲ collagen and the ratios were analyzed.Results:①The ratio of type Ⅰ/type Ⅲcollagen of normal skin had a guadually increasing tendency.②The ratio of type Ⅰ/type Ⅲ collagen of HTS was increasing compared with normal skin(NS)

and relative quantities of type I collagen of HTS was significantly increasing.The ratio of type Ⅰ/type Ⅲcollagen of HTS in group of 1～19 year old was highter than that in the group of 20～50 year old .Conclusion:Normal structure of the skin is decided by quantities and ratio of type I and type Ⅲ collagen.The formation of hypertrophic scar in different age periods relates to maladjustment of the ratio of type I and type Ⅲ collagen.Collagen synthesis and regulation of its constitute are finished after about six months.They keep relatively stable within 6 month to 2～3 years.

关键词

瘢痕肥大性胶原免疫组化

Keywords

Hypertrophic scarType I collagenType Ⅲ collagenimmunohistochemistry

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