Objective:To evaluate the clinical therapeutic effect of L-glutamine granules on intestinal damage of severe burn patients and the safety of the drug.Methods:Twenty-two severe burn patients were randomly divided into control group(C group

n =11) and L-glutamine treatment group ( n =11).GLN treatment group were given L-glutamine in a dose of 30g per day for 7 days and C group were given equal amount of placebo.The plasma L-glutamine concentration

the severity of intestinal mucosa damage

the level of plasma protein and parameters of immunological function were observed and the length of hospital stay was recorded.Results:After 7 days of taking L-glutamine orally

plasma L-glutamine concentration was significantly higher and the severity of intestinal mucosal damage were slighter in GLN treatment group than those in C group.The level of plasma protein and parameters of immunological function were higher in GLN treatment group than those in C group.In addition

the length of hospital stay was shorter in GLN treatment group than those in C group.Conclusion:Administration of L-glutamine can raise the plasma GLN level

abate the severity of intestinal damage obviously

maintain the barrier function of intestinal mucosa

enhance the immunological function

correct the negative nitrogen balance and promote the wound healing with no complications.