Observation of the efficacy of leflunomide and methotrexate in the  treatment of rheumatoid arthritis

ZHONG Qing; et al

doi:10.13406/j.cnki.cyxb.2003.04.029

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Observation of the efficacy of leflunomide and methotrexate in the treatment of rheumatoid arthritis

更新时间：2024-01-17

- Observation of the efficacy of leflunomide and methotrexate in the treatment of rheumatoid arthritis
- Journal of Chongqing Medical University Issue 4, Pages: 503-505(2003)
- 作者机构：
  
  1. 重庆医科大学临床学院肾内科
  2. 重庆医科大学临床学院肾内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.04.029
  CLC： R593.22
- Published：2003，
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[1]钟清,甘华,陈恩静,李曼丽.来氟米特治疗类风湿关节炎的临床疗效评价[J].重庆医科大学学报,2003(04):503-505+524.

ZHONG Qing, et al. Observation of the efficacy of leflunomide and methotrexate in the treatment of rheumatoid arthritis. [J]. Journal of Chongqing Medical University (4):503-505(2003)
[1]钟清,甘华,陈恩静,李曼丽.来氟米特治疗类风湿关节炎的临床疗效评价[J].重庆医科大学学报,2003(04):503-505+524. DOI： 10.13406/j.cnki.cyxb.2003.04.029.

ZHONG Qing, et al. Observation of the efficacy of leflunomide and methotrexate in the treatment of rheumatoid arthritis. [J]. Journal of Chongqing Medical University (4):503-505(2003) DOI： 10.13406/j.cnki.cyxb.2003.04.029.

摘要

目的 :观察来氟米特（leflunomide

LEF）治疗类风湿关节炎（RA）的临床疗效和安全性

并以氨甲蝶吟（methotrexate

MTX）作为对照。方法 :5 0例活动性RA患者随机分为两组 :一组口服LEF首始剂量 5 0mg/d连用 3天

继以 2 0mg/d维持

另一组口服小剂量MTX 7.5～ 10mg/周

监测治疗前、1月后和 3月后关节晨僵时间、关节肿胀数、关节疼痛数、ESR、CRP、RF和不良反应。结果 :观察显示LEF组服药 2～ 3周后临床症状逐渐缓解

MTX组服药 5～ 6周后临床症状逐渐缓解。治疗 1月后

LEF组总有效率为 73.34%

MTX组为 4 0 .0 0 % （P <0 .0 5 ） ;两组患者各项临床及生化指标相比差异有显著性（P <0 .0 5 ）。治疗 3月后

LEF组总有效率为 90 .0 0 %

MTX组为 85 .0 0 % （P >0 .0 5 ） ;两组患者各项临床及生化指标与治疗前比较差异有显著性（P <0 .0 0 1） ;LEF组与MTX组相比各项临床及生化指标差异无显著性（P >0 .0 5 ）。两组不良反应发生率相比差异无显著性（P >0 .0 5 ）

但LEF组不良反应程度较MTX组轻。结论 :LEF治疗RA见效快、疗效确切、安全

且耐受性较好。

Abstract

Objective:To evaluate the efficacy and safety of leflunomide (LEF) in comparison with methotrexate (MTX) in treatment of rheumatoid arthritis (RA).Methods:50 patients with active RA were randomly divided into two groups.The first group received 20 mg daily LEF.The second group received small dose (7.5～10 mg weekly) of MTX.We compared the degree of the morning stiffness and the number of swelling

aching joints and the change of ESR

CRP and RF in RA patients between LEF group and MTX group.Results:The response rate in the LEF group was higher than that in the MTX group 1 month later( P <0.05).The response rate was not different between the LEF group and the MTX group 3 months later ( P >0.05).1 month after therapy

the clinical situation and experimental findings were much ameliorated in LEF group as compared with before ( P <0.05).Significant difference in the clinical manifestations and experimental findings were found between LEF group and MTX group ( P <0.05).3 months after therapy

the clinical situation and experiment findings were much ameliorated in both groups ( P <0.001) .No significant difference in the clinical manifestations and experimental findings were found between LEF group and MTX group ( P > 0.05) . The incidence of adverse events for LEF and MTX groups were 3/30 and 2/20 respectively

and there was no significant difference ( P >0.05).Conclusion:LEF is an effective agent for treatment ofRA with better tolerability

and there are few adverse effects.

关键词

类风湿关节炎来氟米特氨甲蝶呤

Keywords

rheumatoid arthritisMethotrexateLeflunomide

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