The change of serum and urinary NO and the relation between NO and blood  pressure in patients with chronic glomerulonephritis at pre-uremic phase

CHEN Xuemei; et al

doi:10.13406/j.cnki.cyxb.2003.04.026

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The change of serum and urinary NO and the relation between NO and blood pressure in patients with chronic glomerulonephritis at pre-uremic phase

更新时间：2024-01-17

- The change of serum and urinary NO and the relation between NO and blood pressure in patients with chronic glomerulonephritis at pre-uremic phase
- Journal of Chongqing Medical University Issue 4, Pages: 493-495(2003)
- 作者机构：
  
  1. 重庆医科大学临床学院急诊科
  2. 重庆医科大学临床学院中医科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.04.026
  CLC： R692.31
- Published：2003，
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[1]陈雪梅,李荣亨.慢性肾小球肾炎非尿毒症期患者血、尿NO与血压的关系[J].重庆医科大学学报,2003(04):493-495.

CHEN Xuemei, et al. The change of serum and urinary NO and the relation between NO and blood pressure in patients with chronic glomerulonephritis at pre-uremic phase. [J]. Journal of Chongqing Medical University (4):493-495(2003)
[1]陈雪梅,李荣亨.慢性肾小球肾炎非尿毒症期患者血、尿NO与血压的关系[J].重庆医科大学学报,2003(04):493-495. DOI： 10.13406/j.cnki.cyxb.2003.04.026.

CHEN Xuemei, et al. The change of serum and urinary NO and the relation between NO and blood pressure in patients with chronic glomerulonephritis at pre-uremic phase. [J]. Journal of Chongqing Medical University (4):493-495(2003) DOI： 10.13406/j.cnki.cyxb.2003.04.026.

摘要

目的 :探讨慢性肾小球肾炎非尿毒症期患者体内一氧化氮（NO）的变化

及其与血压的关系。方法 :应用化学比色法

测定 92例慢性肾炎非尿毒症期患者及 31例正常人的血清、尿NO-3 /NO-2 变化。结果 :慢性肾炎非尿毒症期患者血清及尿NO-3 /NO-2 水平较对照组显著降低（P <0 .0 1） ;慢性肾炎非尿毒症期患者高血压组血清及尿NO-3 /NO-2 水平显著低于血压正常组及正常对照组

血压正常组尿NO-3 /NO-2 水平显著低于正常对照组（P <0 .0 5 ） ;患者组血清及尿NO-3 /NO-2 水平均与平均动脉压呈显著负相关。结论 :慢性肾炎非尿毒症期患者高血压的发生可能与体内NO水平不足密切相关。

Abstract

Objective:To observe the change of serum and urinary nitric oxide (NO) and the relation between NO and blood pressure in chronic glomerulonephritis (CGN) patients at pre-uremic phase.Methods:The levels of serum and urinary NO - 3/NO - 2 were measured in 92 cases of CGN at pre-uremic phase and 31 normal subjects by chemical colorimetry.Results:The levels of serum and urinary NO - 3/NO - 2 in CGN patients at pre-uremic phase were significantly lower than those in the control group.The levels of serum and urinary NO - 3/NO - 2 of the hypertension group were significantly lower than those of the normal blood pressure group and the control group;furthermore

the levels of urinary NO - 3/NO - 2 of the normal blood pressure group were significantly lower than those of the control group.There was significantly inverse correlation between the levels of serum NO - 3/NO - 2 and mean arterial pressure (MAP)

and also there was significantly inverse correlation between the levels of urinary NO - 3/NO - 2 and MAP.Conclusion:In CGN patients at pre-uremic phase

hypertension may be related to the insufficiency of NO.

关键词

慢性肾小球肾炎一氧化氮血压

Keywords

Chronic glomerulonephritisnitric oxideBlood pressure

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