Tibolone relieves the symptoms of functional dyspepsia in menopausal women

GU Sai; et al

doi:10.13406/j.cnki.cyxb.2003.04.024

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Tibolone relieves the symptoms of functional dyspepsia in menopausal women

更新时间：2024-01-17

- Tibolone relieves the symptoms of functional dyspepsia in menopausal women
- Journal of Chongqing Medical University Issue 4, Pages: 487-490(2003)
- 作者机构：
  
  1. 重庆医科大学临床学院消化内科
  2. 重庆医科大学临床学院消化内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.04.024
  CLC： R57
- Published：2003，
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[1]古赛,唐承薇.替勃龙改善绝经期功能性消化不良症状[J].重庆医科大学学报,2003(04):487-490.

GU Sai, et al. Tibolone relieves the symptoms of functional dyspepsia in menopausal women. [J]. Journal of Chongqing Medical University (4):487-490(2003)
[1]古赛,唐承薇.替勃龙改善绝经期功能性消化不良症状[J].重庆医科大学学报,2003(04):487-490. DOI： 10.13406/j.cnki.cyxb.2003.04.024.

GU Sai, et al. Tibolone relieves the symptoms of functional dyspepsia in menopausal women. [J]. Journal of Chongqing Medical University (4):487-490(2003) DOI： 10.13406/j.cnki.cyxb.2003.04.024.

摘要

目的 :探讨替勃龙能否改善绝经期功能性消化不良患者临床症状及其相关机制。方法 :14 3例绝经期功能性消化不良患者随机分成 3组

分别给予替勃龙、西沙必利及替勃龙 +西沙必利

治疗 4周

观察治疗前后各组患者上腹胀痛、餐后胀满、早饱、暖气等临床症状积分的变化。在随机分成的 3组中再随机各抽出 2 0例患者治疗前后测定胃 30min排空率及胃半排空时间

观察治疗前后胃动力的变化。结果 :3组药物治疗后 2周和 4周上腹胀痛、餐后胀满症状积分均明显下降。西沙必利治疗后 2周和 4周对早饱、暖气症状无明显缓解

替勃龙及替勃龙 +西沙必利则对所观察的所有症状均有明显缓解

替勃龙改善早饱和嗳气症状优于西沙必利

但与西沙必利合用无增强效应。 3种药物治疗后

胃 30min排空率均明显增加、胃半排空时间缩短

与治疗前比较有显著差异（P <0 .0 5 ）

但 3种治疗方案之间无显著性差异（P >0 .0 5 ）。结论 :替勃龙能通过增强胃动力

明显改善部分绝经期功能性消化不良患者的临床症状

疗效优于促动力药。

Abstract

Objective:To investigate the effect of tibolone on the symptoms of functional dyspepsia in menopausal women.Methods:143 menopausal patients with functional dyspepsia were divided into 3 groups at random.They were treated with tibolone or cisapride or both drugs respectively for 4 weeks.The scores of symptoms including epigastric pain and fullness

abdominal distention after meal

early satiety and belching were recorded before and after 2 or 4 weeks’ treatment.From the 3 guoups we drew out 20 patients at random.The gastric emptying was measured before and after 4 weeks’ treatment respectively.Results:The symptoms of epigastric pain and fullness

abdominal distention after meal were improved after 2

4 weeks’ treatment in three groups.Either tibolone or tibolone combined with cisapride remarkably relieved early satiety and belching

but no response was observed in the treatment of cisapride.The combination of tibolone and cisapride did not show better effect than tibolone treatment alone.The 30-min gastric emptying rates of all groups were significantly improved ( P <0.05) after 4 weeks’ treatment.No difference was observed between three groups ( P >0.05).Conclusion:Compared with cisapride

tibolone can increase gastric emptying and show better relief for the symptoms of functional dyspepsia in menopausal patients.

关键词

功能性消化不良替勃龙绝经期胃动力

Keywords

Functional dyspepsiaTiboloneMenopauseGastric emptying

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