Expression significance of MMP9,MMP2 and PCNA  in transitional cell carcinoma of bladder

PENG Dongtao; et al

doi:10.13406/j.cnki.cyxb.2003.04.018

您当前的位置：

首页 >

文章列表页 >

Expression significance of MMP9,MMP2 and PCNA in transitional cell carcinoma of bladder

更新时间：2024-01-17

- Expression significance of MMP9,MMP2 and PCNA in transitional cell carcinoma of bladder
- Journal of Chongqing Medical University Issue 4, Pages: 467-469(2003)
- 作者机构：
  
  1. 重庆医科大学临床学院泌尿外科
  2. 重庆医科大学临床学院泌尿外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.04.018
  CLC： R737.14
- Published：2003，
扫描看全文
[1]彭东涛,苟欣,何梓铭.膀胱癌组织中MMP9、MMP2与PCNA及临床指标的研究[J].重庆医科大学学报,2003(04):467-469.

PENG Dongtao, et al. Expression significance of MMP9,MMP2 and PCNA in transitional cell carcinoma of bladder. [J]. Journal of Chongqing Medical University (4):467-469(2003)
[1]彭东涛,苟欣,何梓铭.膀胱癌组织中MMP9、MMP2与PCNA及临床指标的研究[J].重庆医科大学学报,2003(04):467-469. DOI： 10.13406/j.cnki.cyxb.2003.04.018.

PENG Dongtao, et al. Expression significance of MMP9,MMP2 and PCNA in transitional cell carcinoma of bladder. [J]. Journal of Chongqing Medical University (4):467-469(2003) DOI： 10.13406/j.cnki.cyxb.2003.04.018.

摘要

目的 :探讨基质金属蛋白酶（MMP9、MMP2 ）在膀胱癌组织中的表达及意义。方法 :采用免疫组织化学S -P法检测6 4例人膀胱移行细胞癌（TCCB）石蜡切片中MMP9、MMP2的表达。结果 :6 4例TCCB组织中

MMP9、MMP2的阳性表达率分别为 6 0 .93% （39/6 4 ）、4 2 .19% （2 7/6 4 ） ;且MMP9的阳性表达率与肿瘤的病理分级和分期

以及肿瘤的大小及PCNA的阳性表达率相关 ;与年龄、性别、肿瘤数目无关。结论 :MMP9的表达可以作为估计TCCB的预后及术后综合治疗的生物学指标。

Abstract

Objective:To study the expression and clinical significance of matrix metalloproteinase(MMP9

MMP2)in transitional cell carcinoma of bladder(TCCB).Methods:Applying S-P immunohistochemical technique

expression of MMP9 and MMP2 was studied in 64 TCCB.Results:There was 60.93%(39/64) with MMP9 and 42.19%(27/64) with MMP2 expression.There was a significant correlation between MMP9 expression and PCNA

pathological grade

clinical stage

tumor size.However

the relationship had not been found with patient age

sex as well as the number of tumor.Conclusion:MMP9 appears to be an independent biological marker for predicting prognosis and comprehensive treatment of TCCB.

关键词

膀胱肿瘤基质金属蛋白酶免疫组织化学

Keywords

Bladder neoplasmsmatrix metalloproteinaseimmunohistochemistry

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Expression and significance of FOXP3 in colon cancer cells

Expression of HIF-1α and Sema4D in pancreatic carcinoma and its clinical significance

HISTOCHEMICAL AND IMMUNOHISTOCHEMI- CAL STUDY OF MAMMAKY PAGET’S DISEASE

THE EXPRESSION AND SIGMFICANCE OF HMB45,S-100 PROTEIN AND VIMENTIN IN PRIMARY MALIGNANT MELANOMA

Histopathologic examination of uterine smooth muscle tumors

Related Author

Qiu Lei

Shao Hua

Miao Yongchang

Jia Rujiang

Yin Qingchen

Wang Xiuchao

Hou Liyan

Xu Chao

Related Institution

Department of Gastrointestinal Surgery,The Second People’s Hospital of Lianyungang City

Department of General Surgery,Handan Central Hospital

Department of Pancreatic Oncology,Tianjin Medical University Cancer Institute and Hospital

重庆医科大学基础医学院病理教研室

重庆医科大学临床学院眼科

⁰