Relationship of STAT3 and VEGF in non-small cell lung cancer

XU Wenchun; et al

doi:10.13406/j.cnki.cyxb.2003.04.016

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Relationship of STAT3 and VEGF in non-small cell lung cancer

更新时间：2024-01-17

- Relationship of STAT3 and VEGF in non-small cell lung cancer
- Journal of Chongqing Medical University Issue 4, Pages: 460-462(2003)
- 作者机构：
  
  1. 重庆医科大学检验系
  2. 重庆医科大学基础医学院病理教研室
  3. 重庆医科大学检验系,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.04.016
  CLC： R734.2
- Published：2003，
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[1]胥文春,罗春丽,冯文莉,林晓,唐敏.STAT3与VEGF在非小细胞肺癌中的表达及关系[J].重庆医科大学学报,2003(04):460-462+466.

XU Wenchun, et al. Relationship of STAT3 and VEGF in non-small cell lung cancer. [J]. Journal of Chongqing Medical University (4):460-462(2003)
[1]胥文春,罗春丽,冯文莉,林晓,唐敏.STAT3与VEGF在非小细胞肺癌中的表达及关系[J].重庆医科大学学报,2003(04):460-462+466. DOI： 10.13406/j.cnki.cyxb.2003.04.016.

XU Wenchun, et al. Relationship of STAT3 and VEGF in non-small cell lung cancer. [J]. Journal of Chongqing Medical University (4):460-462(2003) DOI： 10.13406/j.cnki.cyxb.2003.04.016.

摘要

目的 :探讨非小细胞肺癌中STAT3蛋白与VEGF表达的关系

以进一步探讨肿瘤的发生及转移机制。方法 :利用SABC免疫组织化学技术检测 4 0例非小细胞肺癌（NSCLC）组织中STAT3蛋白和VEGF的表达。结果 :（1）STAT3在低分化肺癌组织中的表达明显高于高分化肺癌组织

在有淋巴结转移肺癌组织中的表达明显高于无淋巴结转移肺癌组织

与肿瘤的大小及组织学类型无关。（2 ）VEGF在直径≥ 3cm肺癌组织中的表达明显高于直径 <3cm肺癌组织

在有淋巴结转移肺癌组织中的表达明显高于无淋巴结转移肺癌组织

与肿瘤的组织学类型及分化程度无关。（3）STAT3与VEGF表达呈显著正相关。结论 :本组资料提示STAT3与VEGF可能在肺癌的发生及转移中发挥重要作用。二者之间的相关性证实VEGF基因直接由STAT3蛋白调节的论点。由此也为目前肿瘤抗血管生成治疗的研究提供了新的证据。

Abstract

Objective:To explore the expression of STAT3 and vascular endothelial growth factor (VEGF) in non-small cell lung cancer (NSCLC) and their relationship.Methods:SABC immunohistochemistry was used to detect the expression of STAT3 and VEGF in non-small tissues of 40 cases.Results:(1)The expression of STAT3 in NSCLCs had a obvious relation with the tumor cell differentiation and lymph node metastasis.No obvious difference in STAT3 expression was found among different tumor sizes of tumor types.(2)The expression of VEGF in NSCLCs had a significant relation with tumor size and lymph node metastasis.There was no significant difference between VEGF expression and tumor types and tumor cell differentiation.(3)There was significant positive correlation between the expression of VEGF and STAT3 in NSCLCs.Conclusion:STAT3 and VEGF may play an important role in the development of NSCLC.We identify that VEGF gene is regulated directly by STAT3 protein.

关键词

非小细胞肺癌STAT3VEGF免疫组化

Keywords

Non-small cell lung cancersSignal transducers and activators of transcription 3vascular endothelial growth factorimmunohistochemistry

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