Effect of different dosage of tamoxifen on the morphology  of the mammary hyperplasia of rats

GAN Changqing; et al

doi:10.13406/j.cnki.cyxb.2003.04.012

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Effect of different dosage of tamoxifen on the morphology of the mammary hyperplasia of rats

更新时间：2024-01-17

- Effect of different dosage of tamoxifen on the morphology of the mammary hyperplasia of rats
- Journal of Chongqing Medical University Issue 4, Pages: 448-450(2003)
- 作者机构：
  
  1. 重庆医科大学临床学院普外科
  2. 重庆医科大学临床学院普外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.04.012
  CLC： R655.8
- Published：2003，
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[1]甘长清,吴凯南,苏新良.三苯氧胺对大鼠乳腺增生形态学的影响[J].重庆医科大学学报,2003(04):448-450.

GAN Changqing, et al. Effect of different dosage of tamoxifen on the morphology of the mammary hyperplasia of rats. [J]. Journal of Chongqing Medical University (4):448-450(2003)
[1]甘长清,吴凯南,苏新良.三苯氧胺对大鼠乳腺增生形态学的影响[J].重庆医科大学学报,2003(04):448-450. DOI： 10.13406/j.cnki.cyxb.2003.04.012.

GAN Changqing, et al. Effect of different dosage of tamoxifen on the morphology of the mammary hyperplasia of rats. [J]. Journal of Chongqing Medical University (4):448-450(2003) DOI： 10.13406/j.cnki.cyxb.2003.04.012.

摘要

目的 :探讨不同剂量的三苯氧胺（TAM ）对实验性乳腺增生症形态学的影响。方法 :用雌二醇和黄体酮诱导Wistar大鼠乳腺增生动物模型。 180只雌性大鼠随机分为六组 :A组 :空白对照组

B组 :模型对照（单用性激素）组

C组 :性激素加TAM （16 6 .7μg）组

D组 :性激素加TAM （333μg）组

E组 :性激素加TAM（5 0 0 μg）组

F组 :性激素加TAM （6 6 7μg）组

喂养 2个月后

经光镜及电镜观察。结果 :光镜观察 :C组、D组用药前后P >0 .0 5

无明显差别。E组、F组P <0 .0 1

用药前后对比有显著差别。说明E组及F组剂量的TAM有明显抑制乳腺增生的作用。结论 :三苯氧胺有抑制雌二醇和黄体酮诱导的Wistar大鼠乳腺增生的作用

尤E组及F组明显。

Abstract

Objective:To study the effect of different dosage of tamoxifen (TAM) on the morphological change of experimental mammary hyperplasia.Methods:The animal model of mammary hyperplasia of Wistar rats was induced with estradiol and progesterone. One hundred and eighty female Wistar rats were selected randomly into group A (control group )

group B (model control group)

group C (166.7 μg dosage of TAM)

group D(333μg dosage of TAM)

group E(500μg dosage of TAM)

and group F(667μg dosage of TAM) and fed for 2 months.Samples of breasts were collected and observed under light microscope and electronmicroscope.Results:For light microscope observation :there were obvious difference between premedication and postmedication in group E and F

respectively ( P <0.01)

but no obvious difference were found in group C and D( P >0. 05)

implying that 500 μg dosage and 667 μg dosage of TAM had obvious inhibitory effect on mammary hyperplasia under light microscope.Conclusion:Through light microscope and electronmicroscope observation

TAM especially 500μg and 667μg dosage proves to have obvious inhibitory effect on mammary hyperplasia induced by estradiol and progesterone.

关键词

三苯氧胺雌二醇黄体酮乳腺增生

Keywords

TamoxifonestradiolProgesteroneMammary hyperplasia

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