Preliminary study on the mechanism and the therapeutic effect of neonatal unconjugated hyperbilirubinemia using microecological preparation

CHEN Yiji; et al

doi:10.13406/j.cnki.cyxb.2003.03.036

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Preliminary study on the mechanism and the therapeutic effect of neonatal unconjugated hyperbilirubinemia using microecological preparation

更新时间：2024-01-17

- Preliminary study on the mechanism and the therapeutic effect of neonatal unconjugated hyperbilirubinemia using microecological preparation
- Journal of Chongqing Medical University Issue 3, Pages: 367-369(2003)
- 作者机构：
  
  1. 重庆医科大学儿科学院新生儿科
  2. 重庆医科大学药物分析室
  3. 四川省内江铁路医院儿科
  4. 重庆医科大学中心实验室,四川,631001
  5. ,重庆,400014
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.03.036
  CLC： R722.1
- Published：2003，
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[1]陈贻骥,梁颖文,吴仕孝,邓彦,余道澄.微生态调节剂干预新生儿高未结合胆红素血症疗效和机制初探[J].重庆医科大学学报,2003(03):367-369.

CHEN Yiji, et al. Preliminary study on the mechanism and the therapeutic effect of neonatal unconjugated hyperbilirubinemia using microecological preparation. [J]. Journal of Chongqing Medical University (3):367-369(2003)
[1]陈贻骥,梁颖文,吴仕孝,邓彦,余道澄.微生态调节剂干预新生儿高未结合胆红素血症疗效和机制初探[J].重庆医科大学学报,2003(03):367-369. DOI： 10.13406/j.cnki.cyxb.2003.03.036.

CHEN Yiji, et al. Preliminary study on the mechanism and the therapeutic effect of neonatal unconjugated hyperbilirubinemia using microecological preparation. [J]. Journal of Chongqing Medical University (3):367-369(2003) DOI： 10.13406/j.cnki.cyxb.2003.03.036.

摘要

目的 :探讨微生态调节剂（MP）对降低新生儿高未结合胆红素血症（UCHB）血清胆红素的疗效及机制。方法 :4 6例UCHB患儿随机分为两组

常规治疗基础上

观察组加服多维乳酸菌散（粪链球菌、枯草杆菌） ;全自动生化分析仪

重氮偶合比色法测血清胆红素。结果 :治疗 72h后血清总胆红素

观察组较控制组降低明显

P <0 .0 5

日均胆红素下降值分别是 4 4 .0 6±7.2 2 μmol/L和 36 .35± 7.19μmol/L

P <0 .0 0 1。结论 :多维乳酸菌散对降低新生儿UCHB有效。MP干预新生儿黄疸几无副作用

顺应了当前医药界维护人体微生态平衡的“绿色革命”。

Abstract

Objective:To study the therapeutic effect and the mechanism of microecological preparation to reduce the serum bilirubin level in neonatal unconjugated hyperbilirubinemia(UCHB).Methods:Forty-six neonates with UCHB were divided into two groups.Beside the conventional treatment

pulvis polyvitamin lactobacillus(E.faecium

B.subtilis)was given to the investigated group.Total serum bilirubin(TSB)levels were determined by diazo coincidence analysis colorimetric method with full automatic biochemical analysor.Results:After the 72-hour treatment

the decreased TSB levels of the investigated group were more obvious than those of the control group

P <0.05.The average value of daily decreased TSB level was 44.06±7.22μmol/L in the former

and 36.35±7.19μmol/L in the latter

P <0.001. Conclusion: Pulvis polyvitamin lactobacillus is an effective drug to reduce the TSB levels in neonatal UCHB

and it accords with the current trend that"green revolution" in medicine to safeguard the ecological balance of human body.

关键词

高未结合胆红素血症婴儿新生微生态调节剂

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