The clinical observation of the treatment of the moderate and severe amblyopia with cytidine-5’ -diphosphocholine

ZHANG Li; et al

doi:10.13406/j.cnki.cyxb.2003.03.035

您当前的位置：

首页 >

文章列表页 >

The clinical observation of the treatment of the moderate and severe amblyopia with cytidine-5’ -diphosphocholine

更新时间：2024-01-17

- The clinical observation of the treatment of the moderate and severe amblyopia with cytidine-5’ -diphosphocholine
- Journal of Chongqing Medical University Issue 3, Pages: 364-366(2003)
- 作者机构：
  
  1. 重庆医科大学临床学院眼科
  2. 重庆医科大学临床学院眼科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.03.035
  CLC： R777.44
- Published：2003，
扫描看全文
[1]张黎,陶永贤.胞二磷胆碱治疗中、重度弱视的临床观察[J].重庆医科大学学报,2003(03):364-366.

ZHANG Li, et al. The clinical observation of the treatment of the moderate and severe amblyopia with cytidine-5’ -diphosphocholine. [J]. Journal of Chongqing Medical University (3):364-366(2003)
[1]张黎,陶永贤.胞二磷胆碱治疗中、重度弱视的临床观察[J].重庆医科大学学报,2003(03):364-366. DOI： 10.13406/j.cnki.cyxb.2003.03.035.

ZHANG Li, et al. The clinical observation of the treatment of the moderate and severe amblyopia with cytidine-5’ -diphosphocholine. [J]. Journal of Chongqing Medical University (3):364-366(2003) DOI： 10.13406/j.cnki.cyxb.2003.03.035.

摘要

目的 :观察胞二磷胆碱治疗中、重度弱视后视力等指标的变化

评估其疗效和可行性。方法 :将 81例弱视患者

随机分成药物组

肌肉注射胞二磷胆碱 ;联合组

药物联合遮盖治疗 ;遮盖组

遮盖治疗加精细作业。严密观察各种可能的副作用。对视力等结果进行统计学分析处理。结果 :药物组视力提高出现最早

但 4月后呈下降趋势。联合组对各种弱视有效

视力能持续性提高。药物组和联合组视网膜光阈值有改善。治疗后三组视觉诱发电位P10 0 波潜伏期均无改善。一例患者注射胞二磷胆碱后诱发癫痫。结论 :胞二磷胆碱能提高弱视眼的视力

改善视网膜光阈值。胞二磷胆碱与遮盖治疗联合应用疗效较好。胞二磷胆碱可诱发癫痫发作。

Abstract

Objective:To observe the change of quotas such as vision acuity

fusion acuity etc after CDP-choline therapy

and evaluate comprehensively the curative effect and feasibility of it.Methods:Eighty-one amblyopic subjects were divided into 3 groups randomly:medical group with CDP-choline administration

combined group CDP-choline administration plus occlusion and meticulous work

occlusion group occlusion and meticulous work.Various kinds of side effects were carefully observed and all results were analyased statistically.Results:The appearance of the improvement of visual acuity in medical group was the earilest

but deteriorated gradually after 4 months.The combined group had improvements in all kinds of amblyopia

lasting throughout the observation period.Retina light sensitivity significantly increased in the medical group and combined group.The latency of the P 100 wave was not improved after the treatment in all of the three groups.Moreover

generalized tonic-clonic seizure was induced by CDP-choline administration in one subject.Conclusion:CDP-choline can improve the VA of amblyopic eyes

and raise the retina light sensitivity.CDP-choline treatment plus occlusion has a better curative effect.CDP-choline may induce seizure.

关键词

胞二磷胆碱弱视药物治疗

Keywords

Cytidine-5-diphosphocholineAmblyopiaMedical therapy

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Change of cytochrome oxidase activity in retina of monocular deprived rats

Investigate the state anxiety and coping style in parents of children with amblyopia

Related Author

YAN Xiuju

et al

周兰新

TU Qin

et al

Related Institution

Department of Ophthalmology, the Second College of Clinical Medicine , Chongqing Medical University

重庆医科大学第二临床学院眼科

Department of Ophthalmology,the First Affiliated Hospital,Chongqing Medical University

重庆医科大学附属第一医院眼科

⁰