Analysis of serum antoantibodies in patients with chronic hepatitis B and patients with cirrhosis caused by hepatitis B

ZHANG Yuhong; et al

doi:10.13406/j.cnki.cyxb.2003.03.032

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Analysis of serum antoantibodies in patients with chronic hepatitis B and patients with cirrhosis caused by hepatitis B

更新时间：2024-01-17

- Analysis of serum antoantibodies in patients with chronic hepatitis B and patients with cirrhosis caused by hepatitis B
- Journal of Chongqing Medical University Issue 3, Pages: 358-359(2003)
- 作者机构：
  
  1. 重庆医科大学临床学院检验科
  2. 重庆医科大学临床学院检验科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.03.032
  CLC： R575.2
- Published：2003，
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[1]张玉洪,叶荻庆,陈瀑,严立.慢性乙型肝炎及乙肝后肝硬化患者血清中自身抗体结果分析[J].重庆医科大学学报,2003(03):358-359+369.

ZHANG Yuhong, et al. Analysis of serum antoantibodies in patients with chronic hepatitis B and patients with cirrhosis caused by hepatitis B. [J]. Journal of Chongqing Medical University (3):358-359(2003)
[1]张玉洪,叶荻庆,陈瀑,严立.慢性乙型肝炎及乙肝后肝硬化患者血清中自身抗体结果分析[J].重庆医科大学学报,2003(03):358-359+369. DOI： 10.13406/j.cnki.cyxb.2003.03.032.

ZHANG Yuhong, et al. Analysis of serum antoantibodies in patients with chronic hepatitis B and patients with cirrhosis caused by hepatitis B. [J]. Journal of Chongqing Medical University (3):358-359(2003) DOI： 10.13406/j.cnki.cyxb.2003.03.032.

摘要

目的 :探讨慢性乙型肝炎及乙肝后肝硬化患者血清中自身抗体的变化情况。方法 :收集了慢性乙型肝炎患者 2 4 5例

乙肝后肝硬化 86例血清标本测定抗核抗体（ANA）和可提取性核抗原（ENA）抗体。结果 :慢性乙型肝炎和乙肝后肝硬化ANA的检出率分别为 13.1% （31/ 2 4 5 ）、2 3.2 % （2 0 / 86 ）

均明显高于正常对照组的 2 .5 % （2 / 80 ）（P <0 .0 5 ）。两组病例间也有显著性差异（P <0 .0 5 ）。抗ENA抗体阳性率分别为 7.34%和 12 .7%。阳性主要有nRNP/Sm、SS -A、Scl- 70、Jo - 1、dsDNA等多种类型。结论 :慢性乙型肝炎及乙肝后肝硬化患者血清自身抗体显著高于正常人。除一部分是目前已鉴定的与常见自身免疫性疾病相关的自身抗体外

还有许多有待进一步鉴定。

Abstract

Objective:To analyze autoantibodies in patients with chronic hepatitis B and patients with cirrhosis cused by hepatitis B.Methods:Both antinuclear antibody(ANA)and anti-extracted nuclear antigen(ENA) antibody were detected in 245 patients with chronic hepatitis B and 86 patients with cirrhosis

respectively.Results:The frequencies of ANA were significantly higher ( P <0.05) in patients with chroic hepatitis B (31/245=13.1%) and cirrhosis (20/86=23.2%).The percentage of patients with cirrhosis was higher than that of the patients with hepatitis B ( P <0.05).The positive rate of anti-ENA antibody was 7.34% in the patients with hepatitis B and 12.7% in the patients with cirrhosis

respectively.The main types for positiveresults were nRNP/Sm

SS-A

Scl-70

Jo-1

and ds-DNA and etc.Conclusion:There are autoantibodies in serum of patients with chronic hepatitis B and patients with cirrhosis caused by hepatitis B.The concentration is higher than normal.Many of them should be further studied for its mechanism.

关键词

乙型肝炎肝硬化自身抗体

Keywords

Hepatits BcirrhosisAutoantibody

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