Expressions and significance of P-gp and nm23,P53 in multiple primary breast carcinoma tissues

SUN Zhijun; et al

doi:10.13406/j.cnki.cyxb.2003.03.019

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Expressions and significance of P-gp and nm23,P53 in multiple primary breast carcinoma tissues

更新时间：2024-01-17

- Expressions and significance of P-gp and nm23,P53 in multiple primary breast carcinoma tissues
- Journal of Chongqing Medical University Issue 3, Pages: 319-321(2003)
- 作者机构：
  
  1. 重庆医科大学临床学院普外科
  2. 重庆医科大学基础医学院病理学教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.03.019
  CLC： R737.9
- Published：2003，
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[1]孙治君,周鑫,姚榛祥,管小琴,李圆圆.P-gp和nm23、P53在多原发乳腺癌组织的表达及意义[J].重庆医科大学学报,2003(03):319-321.

SUN Zhijun, et al. Expressions and significance of P-gp and nm23,P53 in multiple primary breast carcinoma tissues. [J]. Journal of Chongqing Medical University (3):319-321(2003)
[1]孙治君,周鑫,姚榛祥,管小琴,李圆圆.P-gp和nm23、P53在多原发乳腺癌组织的表达及意义[J].重庆医科大学学报,2003(03):319-321. DOI： 10.13406/j.cnki.cyxb.2003.03.019.

SUN Zhijun, et al. Expressions and significance of P-gp and nm23,P53 in multiple primary breast carcinoma tissues. [J]. Journal of Chongqing Medical University (3):319-321(2003) DOI： 10.13406/j.cnki.cyxb.2003.03.019.

摘要

目的 :研究多原发乳腺癌组织P - gp和nm2 3、P5 3变化规律

探讨P - gp和nm2 3、P5 3与多原发癌发生的关系

方法 :应用免疫组化检测 34例良恶性乳腺组织中P - gp、nm2 3、P5 3的表达

并比较其阳性表达率和程度的差异。结果 :多原发乳腺癌和无复发乳腺癌组织P5 3阳性表达率均较乳腺纤维腺瘤组织高

多原发乳腺癌P5 3阳性表达程度高于无复发乳腺癌。结论 :P5 3可反映癌组织细胞增殖活性

P5 3过表达预测第二原发癌发生具有一定价值。

Abstract

Objective: To study the expression of P-gp and nm23

P53 in multiple primary breast carcinoma tissues and to evaluate the prediction significance in occurrence of the second primary carcinoma. Methods:Expression of P-gp

nm23

P53 in 34 benign and malignant breast paraffin-embedded specimens

the difference of the rate and the intensity of positive reaction of P-gp

nm23

P53 were checked.Results:The positive rate of P53 was significantly increased in malignant breast tissues compared with benign breast tissues

the positive intensity of P53 was significantly increased in multiple breast carcinoma tissues compared with the tissues of no occurrence of breast carcinoma. Conclusion:The expression of P53 may indicate the proliferating activity of carcinoma cell. The positive intensity of expression of P53 can be certain valuable in prediction of the occurrence of second primary carcinoma.

关键词

多原发乳腺癌P-糖蛋白癌转移抑制基因癌基因表达

Keywords

Multiple primary breast carcinomaP-gpnm23P53

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