Clinicopathological value of immunohistochemical detection of micrometastases in pT3N0M0 gastric cancer

WANG Ziwei; et al

doi:10.13406/j.cnki.cyxb.2003.03.006

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Clinicopathological value of immunohistochemical detection of micrometastases in pT₃N₀M₀ gastric cancer

更新时间：2024-01-17

- Clinicopathological value of immunohistochemical detection of micrometastases in pT₃N₀M₀ gastric cancer
- Journal of Chongqing Medical University Issue 3, Pages: 273-275(2003)
- 作者机构：
  
  1. 重庆医科大学临床学院普外科
  2. 重庆医科大学临床学院普外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.03.006
  CLC： R735.2
- Published：2003，
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[1]王子卫,张才全,王严庆.PT_3N_0M_0胃癌病人淋巴结微转移的临床病理学意义[J].重庆医科大学学报,2003(03):273-275.

WANG Ziwei, et al. Clinicopathological value of immunohistochemical detection of micrometastases in pT₃N₀M₀ gastric cancer. [J]. Journal of Chongqing Medical University (3):273-275(2003)
[1]王子卫,张才全,王严庆.PT_3N_0M_0胃癌病人淋巴结微转移的临床病理学意义[J].重庆医科大学学报,2003(03):273-275. DOI： 10.13406/j.cnki.cyxb.2003.03.006.

WANG Ziwei, et al. Clinicopathological value of immunohistochemical detection of micrometastases in pT₃N₀M₀ gastric cancer. [J]. Journal of Chongqing Medical University (3):273-275(2003) DOI： 10.13406/j.cnki.cyxb.2003.03.006.

摘要

目的 :探讨淋巴结微转移在pT3 N0 M0 胃癌病人中的临床意义。方法 :用细胞角蛋白免疫组化染色法检测了 1980年— 1995年间手术的 95例二期胃癌（pT3 N0 M0 ）病人的 2 2 30个淋巴结。结果 :38例（4 0 % ）胃癌发现有 2 90个淋巴结（13% ）存在隐匿性转移。低分化腺癌微转移发生率高于高分化腺癌

淋巴结微转移阳性病人的 5年生存率明显低于淋巴结微转移阴性病人（P <0 .0 1）。结论 :将淋巴结的细胞角蛋白特殊免疫染色与常规组织学检查结合起来

能够更准确地判断 pT3 N0 M0 病人的预后。

Abstract

Objective:Exploring the significance of micrometastases of lymph nodes in cases of pT 3N 0M 0 gastric cancer.Methods:We examined 2230 lymph nodes that had been removed from 95 patients with stage Ⅱ gastric cancer(pT 3N 0M 0) with immunostaining of cytokeratin.Results:In 38 of 95(40%) patients with gastric cancer

evidence of micrometastases was found in 290 of 2230(13%) lymph nodes.The incidence of micrometastases in undifferentiated carcinoma was higher than that in differentiated carcinoma.An analysis of survival demonstrated the 5-year survival of patients with micrometastases in their resected lymph nodes was significantly lower than that of patients without micrometastases( P <0.01).Conclusion:The accuracy of prediction of prognosis of patients with pT 3N 0M 0 gastric cancer should be greatly enhanced if cytokeratin-specific immunostaining is performed in conjunction with routine histopathological examination of lymph nodes.

关键词

胃癌微转移细胞角蛋白免疫组化法

Keywords

gastric cancerMicrometastasesCytokeratinImmunohistochemistry

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