Clinical efficacy and safety evaluation of cefdinir in the treatment of skin and soft tissue bacterial infections

ZENG Aizhong; et al

doi:10.13406/j.cnki.cyxb.2003.02.036

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Clinical efficacy and safety evaluation of cefdinir in the treatment of skin and soft tissue bacterial infections

更新时间：2024-01-17

- Clinical efficacy and safety evaluation of cefdinir in the treatment of skin and soft tissue bacterial infections
- Journal of Chongqing Medical University Issue 2, Pages: 230-232(2003)
- 作者机构：
  
  1. 重庆医科大学临床学院感染科
  2. 重庆医科大学临床学院感染科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.02.036
  CLC： R969
- Published：2003，
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[1]曾爱中,辛小娟,肖永红,陈海.头孢地尼治疗36例皮肤软组织感染临床疗效及抗菌活性观察[J].重庆医科大学学报,2003(02):230-232.

ZENG Aizhong, et al. Clinical efficacy and safety evaluation of cefdinir in the treatment of skin and soft tissue bacterial infections. [J]. Journal of Chongqing Medical University (2):230-232(2003)
[1]曾爱中,辛小娟,肖永红,陈海.头孢地尼治疗36例皮肤软组织感染临床疗效及抗菌活性观察[J].重庆医科大学学报,2003(02):230-232. DOI： 10.13406/j.cnki.cyxb.2003.02.036.

ZENG Aizhong, et al. Clinical efficacy and safety evaluation of cefdinir in the treatment of skin and soft tissue bacterial infections. [J]. Journal of Chongqing Medical University (2):230-232(2003) DOI： 10.13406/j.cnki.cyxb.2003.02.036.

摘要

目的 :以头孢地尼和头孢特仑酯随机对照治疗急性皮肤、软组织感染

评价头孢地尼的疗效及安全性。方法 :18例患者接受头孢地尼 10 0～ 2 0 0mg

每日 3次 ;18例接受头孢特仑酯 10 0～ 2 0 0mg

每日 3次

疗程 7～ 14天。结果 :试验组和对照组痊愈率和有效率分别为 77.8%、72 .7% （P >0 .0 5 ）与 94 .4 %、88.9% （P >0 .0 5 ）。两组的细菌阳性率、清除率分别为 83.3%、88.9% （P >0 .0 5 ）和 93.3%、87.5 % （P >0 .0 5 ）。临床分离的 31株致病菌对头孢地尼、头孢特仑酯、头孢克肟、头孢克洛、阿莫西林和环丙沙星的敏感率分别为 10 0 %、10 0 %、6 7.8%、86 .5 %、6 2 .3%和 6 6 .1% ;头孢地尼与头孢特仑酯、头孢克洛相比差异无显著性（P >0 .0 5 ）

但与头孢克肟、阿莫西林和环丙沙星相比差异有显著性（P <0 .0 5 ）。两组不良反应发生率分别为 0和 6 .2 5 % （P >0 .0 5 ）。结论 :头孢地尼治疗轻、中度细菌感染安全、有效。

Abstract

Objective: To evaluate the clinical efficacy and safety of cefdinir in the treatment of mild and moderate skin and soft tissue bacterial infections. Methods: 18 patients in study group were treated with cefdinir 100～200mg per oral three times a day and 18 patients in control group with cefteram pivoxil 100～200mg per oral three times a day for 7 to 14 days. Results: The cure rates and the effective rates of the two groups were 77.8%

72.7% (P>0.05) and 94.4%

88.9% (P >0.05)

respectively.The bacterial positive and eradication rates of the two groups were 83.3%

88.9% (P >0.05) and 93.3%

87.5% (P >0.05)

respectively.Sensitivity rates of 31 bacterial strains to cefdinir

cefteram pivoxil

cefixime

cefaclor

amoxacillin and ciprofloxacin were 100%

100%

67.8%

86.5%

62.3% and 66.1%

respectively.Adverse events rates of the two groups were 0.0% and 6.25%

respectively.No significant statistic difference was detected between the two groups. Conclusion: The efficacy and safty of cefdinir in the treatment of mild and moderate skin and soft tissue bacterial infections is reliable.

关键词

头孢地尼头孢特仑酯临床疗效细菌性感染

Keywords

CefdinirClinical efficacySafetyBacterial infections

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