Clinical significance and expression of p53,C-erbB-2 and PCNA in bronchioloaveolar carcinoma

CHEN Shifeng; et al

doi:10.13406/j.cnki.cyxb.2003.02.027

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Clinical significance and expression of p53,C-erbB-2 and PCNA in bronchioloaveolar carcinoma

更新时间：2024-01-17

- Clinical significance and expression of p53,C-erbB-2 and PCNA in bronchioloaveolar carcinoma
- Journal of Chongqing Medical University Issue 2, Pages: 205-207(2003)
- 作者机构：
  
  1. 重庆医科大学第二临床学院心胸外科
  2. 重庆医科大学第二临床学院心胸外科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.02.027
  CLC： R734.1
- Published：2003，
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[1]陈诗奉,江跃全.P53、C-erbB-2、PCNA在细支气管肺泡细胞癌中的表达及临床意义[J].重庆医科大学学报,2003(02):205-207+212.

CHEN Shifeng, et al. Clinical significance and expression of p53,C-erbB-2 and PCNA in bronchioloaveolar carcinoma. [J]. Journal of Chongqing Medical University (2):205-207(2003)
[1]陈诗奉,江跃全.P53、C-erbB-2、PCNA在细支气管肺泡细胞癌中的表达及临床意义[J].重庆医科大学学报,2003(02):205-207+212. DOI： 10.13406/j.cnki.cyxb.2003.02.027.

CHEN Shifeng, et al. Clinical significance and expression of p53,C-erbB-2 and PCNA in bronchioloaveolar carcinoma. [J]. Journal of Chongqing Medical University (2):205-207(2003) DOI： 10.13406/j.cnki.cyxb.2003.02.027.

摘要

目的 :研究p5 3、C -erbB - 2基因蛋白和细胞增殖核抗原（PCNA）的表达与细支气管肺泡细胞癌（bronchioloaveolarcarcinoma

BAC）临床病理特征的关系。方法 :应用免疫组化法检测 36例BAC（局限型 2 5例

弥漫型 11例）组织中 p5 3、C -erbB - 2、PCNA的表达水平。结果 :弥漫型 p5 3阳性率和PCNA增殖指数分别为 81.82 %和 72 .2 3± 8.5 9

明显高于局限型36 .0 0 %和 4 6 .14± 6 .2 0

（P <0 .0 5 ）。C -erbB - 2阳性表达在两型中无明显差异

p5 3和PCNA阳性表达均与淋巴结转移有关

而且PCNA表达亦与P -TNM分期密切相关（P <0 .0 5 ）。弥漫型伴淋巴结转移的发生率和淋巴结阳性数目（72 .73%

平均 2 .6 3枚）较局限型者（5 2 .0 %

平均 2 .0枚）高

其 p5 3、C -erbB - 2阳性表达的程度亦较局限型有或无淋巴结转移者强。结论 :p5 3基因蛋白和PCNA的表达对BAC预后的评价有一定的参考价值

弥漫型BAC更具有恶性肿瘤的生物学行为

Abstract

Objective: To study the clinical significance and expression of p53

C-erbB-2 and PCNA in bronchioloaveolar carcinoma (BAC). Methods: Thirty-six cases of BAC were collected (25 cases localized type and 11 cases diffused type).The expression of p53

C-erbB-2 and PCNA in BAC tissues was determined with immunohistochemical methods. Results: The positive rate of p53 gene protein expression and PCNA proliferating index in the diffused type were 81.82% and 72.23±8.59 respectively

which were both significantly higher than 36.00% and 46.14±6.20 of those in the localized type ( P< 0.05);there was no significant difference on C-erbB-2 in the localized type and diffused type;the positive expression of p53 and PCNA was significantly related to the lymph node metastasis

and PCNA proliferating index was closely related to the P-TNM staging ( P <0.05).The lymph node numbers and positive rate (2.63

72.73%) of the diffused type with the lymph node metastasis were higher than those (2.0

52.0%) in the localized type and the positive expression of p53

C-erbB-2 gene protein were more severe than the localized type with or not. Conclusion: The expression of p53and PCNA could be quite valuable in the prognostic evaluation of BAC and the diffuse BAC could possess more biological characteristics of the malignant tumor.

关键词

细支气管肺泡细胞癌免疫组化法p53C-erbB-2PCNA

Keywords

Bronchioloaveolar carcinomaImmunohistochemical methodsp53C-erbB-2PCNA

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