Significance of anti-nucleosome antibodies in systemic lupus erythematosus

CHEN Pu; et al

doi:10.13406/j.cnki.cyxb.2003.02.021

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Significance of anti-nucleosome antibodies in systemic lupus erythematosus

更新时间：2024-01-17

- Significance of anti-nucleosome antibodies in systemic lupus erythematosus
- Journal of Chongqing Medical University Issue 2, Pages: 187-188(2003)
- 作者机构：
  
  1. 重庆医科大学临床学院检验科
  2. 重庆医科大学临床学院肾内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.02.021
  CLC： R593.241
- Published：2003，
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[1]陈瀑,钟清.系统性红斑狼疮患者血清抗核小体抗体检测的意义[J].重庆医科大学学报,2003(02):187-188+216.

CHEN Pu, et al. Significance of anti-nucleosome antibodies in systemic lupus erythematosus. [J]. Journal of Chongqing Medical University (2):187-188(2003)
[1]陈瀑,钟清.系统性红斑狼疮患者血清抗核小体抗体检测的意义[J].重庆医科大学学报,2003(02):187-188+216. DOI： 10.13406/j.cnki.cyxb.2003.02.021.

CHEN Pu, et al. Significance of anti-nucleosome antibodies in systemic lupus erythematosus. [J]. Journal of Chongqing Medical University (2):187-188(2003) DOI： 10.13406/j.cnki.cyxb.2003.02.021.

摘要

目的 :探讨血清抗核小体抗体（ANuA）的检测在系统性红斑狼疮患者中的意义。方法 :采用酶联免疫吸附试验检测5 8例SLE患者

4 3例其它结缔组织病患者

2 0例非结缔组织病患者及 2 0例健康人血清抗核小体抗体。结果 :SLE患者血清ANuA阳性率为 74 .1%。SLE患者与健康对照组血清中ANuA阳性率差别具有高度显著性（P <0 .0 0 1）

而其它结缔组织病和非结缔组织病与健康对照组血清中ANuA阳性率差别均无显著性（P >0 .0 5 ）。SLE活动期患者与非活动期患者ANuA阳性率差别具有高度显著性（P <0 .0 0 1）。结论 :ANuA可以作为除抗dsDNA和抗Sm以外的诊断SLE和判断SLE活动期的一种新的自身抗体。

Abstract

Objective: To study the clinical significance of determining serum anti-nucleosome antibodies(ANuA) in systemic lupus erythematosus patients(SLE). Methods: ANuA were detected by enzyme-linked immunoadsordent assay(ELISA) in the serum of 58 SLE patients

43 patients with different connective diseases(CTD) except SLE

20 patients with non-CTD and 20 normal subjects.Results: The positive rate of ANuA in SLE is 74.1%.Compared with normal

the positive rate of ANuA in the groups of CTD except SLE and the groups of non-CTD was not significantly different( P >0.05) and there was significant difference between the groups of SLE and normal ( P< 0.001).The positive rate of ANuA was significantly different between the active SLE and the non-active SLE. Conclusion: Besides anti-dsDNA and anti-Sm

anti-nucleosome antibodies may be a useful marker for diagnosis and activity assessment of SLE.

关键词

系统性红斑狼疮抗核小体抗体酶联免疫吸附试验

Keywords

systemic lupus erythematosusAnti-nucleosome antibodiesELISA

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