Study on the long-term clearance rate of HBeAg and HBsAg of chronic hepatitis B

WU Guicheng; et al

doi:10.13406/j.cnki.cyxb.2003.02.015

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Study on the long-term clearance rate of HBeAg and HBsAg of chronic hepatitis B

更新时间：2024-01-17

- Study on the long-term clearance rate of HBeAg and HBsAg of chronic hepatitis B
- Journal of Chongqing Medical University Issue 2, Pages: 169-171(2003)
- 作者机构：
  
  1. 重庆医科大学病毒性肝炎研究所
  2. 重庆医科大学病毒性肝炎研究所,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.02.015
  CLC： R512.62
- Published：2003，
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[1]巫贵成,周卫平,赵有蓉,郭树华,王志毅,张定凤.慢性乙型肝炎HBeAg和HBsAg的远期转阴率随访[J].重庆医科大学学报,2003(02):169-171.

WU Guicheng, et al. Study on the long-term clearance rate of HBeAg and HBsAg of chronic hepatitis B. [J]. Journal of Chongqing Medical University (2):169-171(2003)
[1]巫贵成,周卫平,赵有蓉,郭树华,王志毅,张定凤.慢性乙型肝炎HBeAg和HBsAg的远期转阴率随访[J].重庆医科大学学报,2003(02):169-171. DOI： 10.13406/j.cnki.cyxb.2003.02.015.

WU Guicheng, et al. Study on the long-term clearance rate of HBeAg and HBsAg of chronic hepatitis B. [J]. Journal of Chongqing Medical University (2):169-171(2003) DOI： 10.13406/j.cnki.cyxb.2003.02.015.

摘要

目的 :对慢性乙型肝炎HBeAg和HBsAg的远期转阴率进行研究

为其预后判断和药物疗效的评估提供佐证。方法 :采用回顾性的方法随访 12 0例 6～ 18年前经肝穿病理组织学诊断的慢性乙型肝炎HBeAg和HBsAg的远期转阴率。结果 :HBeAg转阴 79/ 82例（96 .34% ）。HBsAg转阴 17/ 12 0例（14 .17% ）。Cox回归分析

LAK细胞、阿糖腺苷、干扰素治疗均有利于HBeAg转阴

病情稳定有利于HBsAg转阴。但 χ2 分析

干扰素等抗病毒治疗组与未抗病毒治疗组的转阴率无显著差异。结论 :慢性乙型肝炎HBeAg的远期自然转阴率高

HBsAg自然转阴率低。

Abstract

Objective: To investigate the long-term clearance rate of HBeAg and HBsAg in chronic hepatitis B to evaluate its long-term outcome

and the antiviral drug efficacy. Methods: 120(mean age 31.53±7.52

male/female 96/24) cases of biopsy-proven chronic hepatitis B were followed up.The follow-up time was 11.77±3.75 years.The study focused on long-term clearance rate of HBeAg and HBsAg. Results: The clearance rate of HBeAg and HBsAg were 96.34% and 14.17%

respectively.Ara-A

LAK cell and interferon were of benefit to clear up HBeAg.Sustained normal serum aspartate aminotransferase level was of benefit to clear HBsAg

but the long-term clearance rate of HBeAg and HBsAg were not statistically different compared to those without antiviral therapy by χ 2 analysis. Conclusion: The long-term natural clearance rate of HBeAg in chronic hepatitis B is high

but HBsAg is low.

关键词

肝炎乙型慢性HBeAgHBsAg转阴率远期

Keywords

Chronic hepatits BHBeAgHBsAgClearance rateLong-term

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Department of Infectious Disease

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