Expression and significance of EGFR,C-erbB<sub>2</sub> and PCNA in multiple primary breast carcinoma tissues

SUN Zhijun; et al

doi:10.13406/j.cnki.cyxb.2003.02.011

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Expression and significance of EGFR,C-erbB₂ and PCNA in multiple primary breast carcinoma tissues

更新时间：2024-01-17

- Expression and significance of EGFR,C-erbB₂ and PCNA in multiple primary breast carcinoma tissues
- Journal of Chongqing Medical University Issue 2, Pages: 156-158(2003)
- 作者机构：
  
  1. 重庆医科大学临床学院普外科
  2. 重庆医科大学基础医学院病理学教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.02.011
  CLC： R737.9
- Published：2003，
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[1]孙治君,周鑫,姚榛祥,管小琴,李圆圆.EGFR、C-erbB_2和PCNA在多原发乳腺癌组织的表达及意义[J].重庆医科大学学报,2003(02):156-158.

SUN Zhijun, et al. Expression and significance of EGFR,C-erbB₂ and PCNA in multiple primary breast carcinoma tissues. [J]. Journal of Chongqing Medical University (2):156-158(2003)
[1]孙治君,周鑫,姚榛祥,管小琴,李圆圆.EGFR、C-erbB_2和PCNA在多原发乳腺癌组织的表达及意义[J].重庆医科大学学报,2003(02):156-158. DOI： 10.13406/j.cnki.cyxb.2003.02.011.

SUN Zhijun, et al. Expression and significance of EGFR,C-erbB₂ and PCNA in multiple primary breast carcinoma tissues. [J]. Journal of Chongqing Medical University (2):156-158(2003) DOI： 10.13406/j.cnki.cyxb.2003.02.011.

摘要

目的 :研究多原发乳腺癌组织EGFR

C -erbB2 和PCNA变化规律

探讨EGFR

C -erbB2 和PCNA预测第二原发癌发生的价值。方法 :应用免疫组化检测 34例良恶性乳腺组织中EGFR、C -erbB2

PCNA的表达

并比较其阳性表达率和程度的差异。结果 :多原发乳腺癌和无复发乳腺癌组织EGFR

C -erbB2

PCNA阳性表达率均较乳腺纤维腺瘤组织高

多原发乳腺癌EGFR

C -erbB2 阳性表达程度高于无复发乳腺癌。结论 :EGFR

C -erbB2

PCNA可反映癌组织细胞增殖活跃

EGFR

C -erbB2 过表达在预测第二原发癌发生具有一定价值。

Abstract

Objective:To study the expression of EGFR

C-erbB 2 and PCNA in multiple primary breast carcinoma tissues and to evaluate the prediction significance in occurrence of the second primary carcinoma . Methods: Expression of EGFR

C-erbB 2

PCNA in 34 benign and malignant breast paraffin-embeded specimens

the difference of the rate and the intensity of positive reaction of EGFR

C-erbB 2

PCNA were checked. Results: The positive rate of EGFR

C-erbB 2

PCNA increased significantly in malignant breast tissues compared with benign breast tissues.The positive intensity of EGFR

C-erbB 2 increased significantly in multiple breast carcinoma tissues compared with tissues of no occurrence of breast carcinoma. Conclusion: The expression of EGFR

C-erbB 2 and PCNA may indicate the proliferating activity of carcinoma cell.The positive intensity of expression of EGFR

C-erbB 2 provided with certain value in prediction of the occurrence of second primary carcinoma.

关键词

多原发乳腺癌表皮生长因子受体癌基因表达增殖细胞核抗原

Keywords

Multiple primary breast carcinomaEGFRC-erbB2PCNA

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⁰

Expression and significance of EGFR,C-erbB2 and PCNA in multiple primary breast carcinoma tissues

DOI：10.13406/j.cnki.cyxb.2003.02.011

摘要

Abstract

关键词

Keywords

references

Expression and significance of EGFR,C-erbB₂ and PCNA in multiple primary breast carcinoma tissues