Endometrioid adenocarcinoma of the ovary:an analysis of  its histologic origin and sex steroid receptor status

ZHAO Yong; et al

doi:10.13406/j.cnki.cyxb.2003.02.010

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Endometrioid adenocarcinoma of the ovary:an analysis of its histologic origin and sex steroid receptor status

更新时间：2024-01-17

- Endometrioid adenocarcinoma of the ovary:an analysis of its histologic origin and sex steroid receptor status
- Journal of Chongqing Medical University Issue 2, Pages: 153-155(2003)
- 作者机构：
  
  1. 重庆医科大学基础医学院病理学教研室
  2. 重庆医科大学基础医学院病理学教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.02.010
  CLC： R737.31
- Published：2003，
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[1]赵涌,李圆圆,罗模珍.卵巢子宫内膜样腺癌:组织学起源分析和性激素受体状态检测[J].重庆医科大学学报,2003(02):153-155.

ZHAO Yong, et al. Endometrioid adenocarcinoma of the ovary:an analysis of its histologic origin and sex steroid receptor status. [J]. Journal of Chongqing Medical University (2):153-155(2003)
[1]赵涌,李圆圆,罗模珍.卵巢子宫内膜样腺癌:组织学起源分析和性激素受体状态检测[J].重庆医科大学学报,2003(02):153-155. DOI： 10.13406/j.cnki.cyxb.2003.02.010.

ZHAO Yong, et al. Endometrioid adenocarcinoma of the ovary:an analysis of its histologic origin and sex steroid receptor status. [J]. Journal of Chongqing Medical University (2):153-155(2003) DOI： 10.13406/j.cnki.cyxb.2003.02.010.

摘要

目的 :探讨子宫内膜异位症（异位症）与卵巢上皮性癌（卵巢癌）的关系

以及雌、孕激素受体、雌激素调节蛋白pS2在卵巢宫内膜样癌组织中的表达及相关性。方法 :对 6 3例卵巢宫内膜样腺癌组织中合并内膜异位症的情况在光镜下进行回顾性观察分析

并用免疫组化对 6 3例病变组织作ER、PR和pS2标记。结果 :6 3例卵巢子宫内膜样癌合并异位症者 8例

有 1例可直接观察到良性异位灶由非典型增生逐渐向宫内膜样腺癌过渡的形态。宫内膜腺癌合并有粘液腺癌者 3例

浆液腺癌者2例。瘤组织中ER、PR和 pS2阳性表达率分别为 38.1% （2 4 / 6 3）、4 6 .2 % （2 6 / 6 3）和 2 5 .4 % （16 / 6 3）。ER和 pS2蛋白阳性表达呈正相关（P <0 .0 1）。结论 :卵巢宫内膜样癌主要来自卵巢生发上皮向子宫内膜方向分化

少数病例来自于异位症病灶恶变。激素与部分肿瘤的发生、发展有关。对肿瘤组织行ER、PR、pS2检测

有助于指导对该肿瘤的激素治疗。

Abstract

Objective:To analyse the relationship between endometriosis and endometrioid adenocarcinoma of the ovary

and investigate the expression of ER

PR and pS2 proteins in endometrioid adenocarcinoma tissue. Methods: 63 cases of endometrioid adenocarcinoma of the ovary were observed retrospectively under the light microscope

and immunohistochemical staining for ER

PR and pS2 were performd in the tumor tissues. Results: Among the 63 cases

there were 8(12.7%)accompanied with endometriosis

of which 1 was observed having transitional lesions ranging from the benign endometriosis to malignant endometrioid carcinoma.Of the 63 cases

Admixtures of endometrioid carcinoma with mucinous were present in 3 cases

and with serous carcinoma in 2.Positive expression rates for ER

PR and pS2 protein in endometrioid carcinoma were 38.1%(24/63)

46.2%(26/63) and 25.4% (16/63)

respectively.There was an apparent correlation between the expressions of ER and pS2 protein ( P <0.01).Conclusion: Endometrioid carcinoma of the ovary originates mainly from the coelomic epithelium of the ovary

and few cases arise from the malignant transformation of endometriosis.The hormones must have some role in the development and growth of the carcinomas.The detection of ER

and pS2 may be helpful in instructing hormone manipulation therapy to endometrioid carcinoma.

关键词

卵巢肿瘤宫内膜样癌子宫内膜异位症ERPRpS2蛋白

Keywords

Ovarian neoplasmsEndometrioid carcinomaendometriosisERPRpS2 protein

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