A study of hypergonadotropic secondary amenorrhea with cytogenetics

ZHANG Jing; et al

doi:10.13406/j.cnki.cyxb.2003.02.009

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A study of hypergonadotropic secondary amenorrhea with cytogenetics

更新时间：2024-01-17

- A study of hypergonadotropic secondary amenorrhea with cytogenetics
- Journal of Chongqing Medical University Issue 2, Pages: 151-152(2003)
- 作者机构：
  
  1. 重庆医科大学基础医学院生物学教研室
  2. 重庆医科大学基础医学院生物学教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.02.009
  CLC： R711.51
- Published：2003，
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[1]张静,唐吟宇,郭玉萍.伴高促性腺激素继发闭经的细胞遗传学研究[J].重庆医科大学学报,2003(02):151-152.

ZHANG Jing, et al. A study of hypergonadotropic secondary amenorrhea with cytogenetics. [J]. Journal of Chongqing Medical University (2):151-152(2003)
[1]张静,唐吟宇,郭玉萍.伴高促性腺激素继发闭经的细胞遗传学研究[J].重庆医科大学学报,2003(02):151-152. DOI： 10.13406/j.cnki.cyxb.2003.02.009.

ZHANG Jing, et al. A study of hypergonadotropic secondary amenorrhea with cytogenetics. [J]. Journal of Chongqing Medical University (2):151-152(2003) DOI： 10.13406/j.cnki.cyxb.2003.02.009.

摘要

目的 :探讨卵巢早衰的发病原因。方法 :采用细胞遗传学的方法

对 10 4例高促性腺激素继发闭经的患者作外周血淋巴细胞染色体检查。结果 :发现 13例患者有性染色体数目或结构异常

占总数的 12 .5 %。其中X染色体数目异常 3例

X染色体结构异常 10例。结论 :本文的研究结果提示X染色体长臂末端可能是卵巢早衰的特异性基因区段并与X染色体末端端粒的缺失有关。

Abstract

Objective:To explore the etiology of premature ovarian failure. Methods: 104 cases of hypergonadotropic secondary amenorrhea were studied cytogenetically. Results: The incidence of chromosomal abnormalities was 12.5%(13/104).Among them

3 cases were numeral abnormalities of X chromosome and 10 cases were structural abnormalities of X chromosome.Conclusion: The result showed that terminal deletion of Xq and telomeric deletion of X chromosome were important factors of premature ovarian failure.

关键词

卵巢早衰X染色体端粒

Keywords

premature ovarian failureX chromosomeTelomere

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