Investigation of T cell subsets, immunoglobul ins and TNF-α of peripheral blood in schizophrenic patients

NIE Changjie; et al

doi:10.13406/j.cnki.cyxb.2003.01.020

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Investigation of T cell subsets, immunoglobul ins and TNF-α of peripheral blood in schizophrenic patients

更新时间：2024-01-17

- Investigation of T cell subsets, immunoglobul ins and TNF-α of peripheral blood in schizophrenic patients
- Journal of Chongqing Medical University Issue 1, Pages: 66-68(2003)
- 作者机构：
  
  1. 重庆医科大学临床学院精神科
  2. 重庆医科大学临床学院精神科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.01.020
  CLC： R749.3
- Published：2003，
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[1]聂长杰,蓝长安.精神分裂症患者细胞免疫及体液免疫的研究[J].重庆医科大学学报,2003(01):66-68.

NIE Changjie, et al. Investigation of T cell subsets, immunoglobul ins and TNF-α of peripheral blood in schizophrenic patients. [J]. Journal of Chongqing Medical University (1):66-68(2003)
[1]聂长杰,蓝长安.精神分裂症患者细胞免疫及体液免疫的研究[J].重庆医科大学学报,2003(01):66-68. DOI： 10.13406/j.cnki.cyxb.2003.01.020.

NIE Changjie, et al. Investigation of T cell subsets, immunoglobul ins and TNF-α of peripheral blood in schizophrenic patients. [J]. Journal of Chongqing Medical University (1):66-68(2003) DOI： 10.13406/j.cnki.cyxb.2003.01.020.

摘要

目的:探讨细胞免疫及体液免疫在精神分裂症病人中的改变及临床意义。方法:用碱性磷酸酶抗碱性磷酸酶桥联酶标法（APAAP）检测T细胞亚群

免疫单扩法检测免疫球蛋白

酶联免疫吸附法（ELISA）检测TNF-α。结果:患者CD

T细胞

T细胞及CD

/CD

T比值均比正常对照显著降低（P

0.01）;lgG含量显著升高（P

0.01）

病程大于5年者CD

T细胞及CD

T细胞降低更明显（P

0.05）;家族史阳性者CD

T细胞

T细胞显著低于家族史阴性者（P

0.05）;CD

T细胞与SAPS总分之间呈负相关（r=-0.34215

P=0.0285）。结论:精神分裂症存在免疫功能低下

其降低的程度受家族史影响

且随病程延长而加剧;病人症状严重程度与免疫功能的降低程度有关。

Abstract

Objective:To investigate the changes and clinical implications of T cell subsets

immunoglobulins and tumor necrosis factor - α (TNF- α) of serum in schizophrenia. Methods: APAAP was used to detect T cell subsets and single immunodiffusion was used to detect immunoglobulins and ELISA was used to detect TNF- α. Results :In 41 patients

CD3+ T cell

CD4+ T cell and CD4+CD8+T cell rates were significantly lower than normal controls(P<0.01) ;lgG was significantly higher(P<0. 01) ;CD3+T cell

CD4+T cell

and CD4+ /CD8+T cell rates in patients with positive family history(24/41) were lower than those with negative family history(P < 0. 01)

Both groups had a significant decrease from normal controls(P<0. 05) ; In addition

there was significant negative correlation between CD3+T cell and SAPS( r = -0.34215

P = 0. 0285). Conclusion :There were decreases of immune function in schizophrenics

which was influenced by inheritance and had a trend of becoming severer according to the length of course. The severity of symptoms of the patients had negative correlation with their immunity.

关键词

精神分裂症T细胞亚群免疫球蛋白肿瘤坏死因子

Keywords

schizophreniaT lymphocyte subsetsimmunoglobulinTNF- α

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