A study of TGF-β1 and bFGF in dilated cadiomyopathy by using immunohistochemistry

DENG Shixiong; et al

doi:10.13406/j.cnki.cyxb.2003.01.019

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A study of TGF-β1 and bFGF in dilated cadiomyopathy by using immunohistochemistry

更新时间：2024-01-17

- A study of TGF-β1 and bFGF in dilated cadiomyopathy by using immunohistochemistry
- Journal of Chongqing Medical University Issue 1, Pages: 62-65(2003)
- 作者机构：
  
  1. 重庆医科大学基础医学院法医学教研室
  2. 重庆市第一中级人民法院,重庆,400016
  3. ,重庆,400012
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.01.019
  CLC： R542.2
- Published：2003，
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[1]邓世雄,谭明红.TGF-β1及bFGF在扩张型心肌病中的表达及其意义研究[J].重庆医科大学学报,2003(01):62-65.

DENG Shixiong, et al. A study of TGF-β1 and bFGF in dilated cadiomyopathy by using immunohistochemistry. [J]. Journal of Chongqing Medical University (1):62-65(2003)
[1]邓世雄,谭明红.TGF-β1及bFGF在扩张型心肌病中的表达及其意义研究[J].重庆医科大学学报,2003(01):62-65. DOI： 10.13406/j.cnki.cyxb.2003.01.019.

DENG Shixiong, et al. A study of TGF-β1 and bFGF in dilated cadiomyopathy by using immunohistochemistry. [J]. Journal of Chongqing Medical University (1):62-65(2003) DOI： 10.13406/j.cnki.cyxb.2003.01.019.

摘要

目的:观察人类DCM心肌组织中TGF-β1及bFGF的蛋白表达情况

探讨TGF-β1及bFGF在DCM心肌结构重塑中的作用及DCM引起猝死的分子机制。方法:采用法医病理尸检收集的30例DCM心脏标本

对心肌组织进行HE染色及TGF β1、TGF β1R、bFGF、bFGFR等细胞生长因子免疫组化染色

对染色结果进行光镜观察和图像分析。结果:TGF-β1表达显著增高

bFGF表达阳性却无统计学意义。结论:TGF-β1是DCM心肌重构发生的重要细胞因子

而bFGF在DCM心肌结构重塑中的作用值得进一步研究。

Abstract

Objective:The aim of the present study is to investigate the expression of TGF- β1 and bFGF in human DCM myocardium

as well as the roles of TGF - β1 and bFGF in DCM myocardium remodeling and the mechanism of sudden death induced by DCM. Methods:30 specimens of DCM heart and control have been collected from forensic pathologic autopsy. Tissues have been prepared by paraffin section for HE staining

and immunohistochemistry with antibodies against TGFβ1

TGFβR1

bFGF

bFGFR. The staining results have been observed with light microscope and analyzed by image processing system. Results:The results showed that the protein expression of the TGF - β1in DCM myocardium was increased

and there was no significant difference of the bFGF protein expression between DCM and controls. Conclusion :The results of this experiment indicate that TGF- β1 is the most important cellular factor in DCM myocardium remodeling

and the role of bFGF in the remodeling of DCM myocardium needs to be further studied.

关键词

扩张型心肌病TGF-β1bFGF免疫组化

Keywords

Dilated cadiomyopathyTGF-β1bFGFimmunohistochemistry

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