Protection of ferulic acid compound in ischemia reperfusion brain injury in rats

CHEN Lifen; et al

doi:10.13406/j.cnki.cyxb.2003.01.015

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Protection of ferulic acid compound in ischemia reperfusion brain injury in rats

更新时间：2024-01-17

- Protection of ferulic acid compound in ischemia reperfusion brain injury in rats
- Journal of Chongqing Medical University Issue 1, Pages: 49-52(2003)
- 作者机构：
  
  1. 重庆医科大学第二临床学院神经内科
  2. 重庆医科大学第二临床学院神经内科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.01.015
  CLC： R741
- Published：2003，
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[1]陈莉芬,胡长林,谢运兰.复方阿魏酸对实验性大鼠脑缺血再灌注损伤的保护作用[J].重庆医科大学学报,2003(01):49-52.

CHEN Lifen, et al. Protection of ferulic acid compound in ischemia reperfusion brain injury in rats. [J]. Journal of Chongqing Medical University (1):49-52(2003)
[1]陈莉芬,胡长林,谢运兰.复方阿魏酸对实验性大鼠脑缺血再灌注损伤的保护作用[J].重庆医科大学学报,2003(01):49-52. DOI： 10.13406/j.cnki.cyxb.2003.01.015.

CHEN Lifen, et al. Protection of ferulic acid compound in ischemia reperfusion brain injury in rats. [J]. Journal of Chongqing Medical University (1):49-52(2003) DOI： 10.13406/j.cnki.cyxb.2003.01.015.

摘要

目的:研究复方阿魏酸对实验性大鼠脑缺血再灌注损伤的保护作用

并探讨其作用机制。方法:采用大鼠双侧颈总动脉阻断和尾部放血并重复缺血再灌的脑缺血模型。观察复方阿魏酸对大鼠脑组织内皮素-1（ET-1）、降钙素基因相关肽（CGRP）、丙二醛、能量代谢、热休克蛋白70（HSP70）表达及病理组织学的影响。结果:复方阿魏酸可以抑制ET-1、丙二醛及乳酸的过量产生

提高脑组织CGRP、ATP及Na

-K

-ATP酶活性。复方阿魏酸的以上作用存在量效关系

其作用优于阳性对照药物丹参。复方阿魏酸治疗组大脑皮层HSP70表达明显增强

大脑缺血损伤程度有减轻。结论:复方阿魏酸对脑缺血再灌注损伤具有保护作用

其机制与改善脑细胞能量代谢、拮抗自由基、改善微循环等多环节作用有关。

Abstract

Objective: To explore the protective effect and its mechanism of the traditional Chinese medicine complex

ferulic acid compound

on cerebral ischemia reperfusion in rats. Methods :Experimental cerebral ischemia reperfusion in rats was made by occluding the two- vessel and bleeding from tails. To observe the effect of ferulic acid compound on levels of endothelin - 1 (ET - 1) 、 calcitonin gene- related peptide (CGRP) 、 malonaldehyde (MDA) 、 energy metabolism 、 the expression of heat shock protein 70 (HSP70) and histopathological analysis in brain tissue. Results:Ferulic acid compound can decrease the level of ET- 1 、 MDA and lactic acid in brain after cerebral ischemia reperfusion in rats

and also improve the contents of CGRP 、 ATP and Na+ - K+ - ATPase activity.The effect of ferulic acid compound was related to dosages

and its effect was better than the positive salvia miltiorrhiza. Eerulic acid compound can increase the HSP70 expression significantly and alleviate cerebral ischemic changes histopathologically. Conclusion :The effect of ferulic acid compound in many ways may be related to its protection against ischemia reperfusion brain injury.

关键词

脑缺血再灌注损伤复方阿魏酸大鼠

Keywords

Cerebral ischemia reperfusion damageFerulic acid compoundrats

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