Vascular endothelial function measured with high- resolution ultrasound in atherogenic diet feeding rabbits

QIN jian; et al

doi:10.13406/j.cnki.cyxb.2003.01.008

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Vascular endothelial function measured with high- resolution ultrasound in atherogenic diet feeding rabbits

更新时间：2024-01-17

- Vascular endothelial function measured with high- resolution ultrasound in atherogenic diet feeding rabbits
- Journal of Chongqing Medical University Issue 1, Pages: 25-28(2003)
- 作者机构：
  
  1. 重庆医科大学临床学院心血管内科
  2. 重庆医科大学临床学院B超室
  3. 重庆医科大学基础医学院药理学教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.01.008
  CLC： R445.1
- Published：2003，
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[1]秦俭,陈运贞,黄晓玲,周歧新,陈受田.高胆固醇高脂喂养兔血管内皮功能的超声检测[J].重庆医科大学学报,2003(01):25-28.

QIN jian, et al. Vascular endothelial function measured with high- resolution ultrasound in atherogenic diet feeding rabbits. [J]. Journal of Chongqing Medical University (1):25-28(2003)
[1]秦俭,陈运贞,黄晓玲,周歧新,陈受田.高胆固醇高脂喂养兔血管内皮功能的超声检测[J].重庆医科大学学报,2003(01):25-28. DOI： 10.13406/j.cnki.cyxb.2003.01.008.

QIN jian, et al. Vascular endothelial function measured with high- resolution ultrasound in atherogenic diet feeding rabbits. [J]. Journal of Chongqing Medical University (1):25-28(2003) DOI： 10.13406/j.cnki.cyxb.2003.01.008.

摘要

目的:以外周动脉超声法

研究喂养高胆固醇高脂不同时间兔的血管内皮功能。方法:12只雌雄各半的日本大耳白兔

随机分为对照组（NC组）和高胆固醇高脂饮食组（HC组）

分别于喂养0、1、2、4、6、8、10、12和14周

以外周髂外动脉超声法

测定血管内皮依赖性舒张功能（EDD）和内皮非依赖性舒张功能（NEDD）。结果:高胆固醇高脂喂养兔1周后

EDD即已发生损害

随着喂养的继续

EDD进一步损害

喂养8周后

NEDD才发生障碍。结论:高胆固醇高脂喂养兔的血管内皮功能明显障碍

EDD障碍发生的时间明显早于NEDD。

Abstract

Objective: To study the vascular endothelial function in atherogenic diet fed rabbits during a variety of feeding time. Methods: 12 Japanese big- eared rabbits were fed either a normal control diet or an atherogenic diet (containing 1 % cholesterol

5% lard and 2% yolk) for 14 weeks. At different feeding times (week0

14)

vascular endothelial functions

including endothelial dependant dilation (EDD) and non- endothelial dependant dilation (NEDD) were measured with high- resolution ultrasound. Results: EDD dysfunction occurred after 1 week of atherogenic diet feeding. With continued feedings

EDD dysfunction was progressively worse. NEDD dysfunction occurred at week 8

much later than EDD dysfunction. Conclusion :Vascular endothelial functions including EDD and NEDD in atherogenic diet fed rabbits were seriously damaged. EDD dysfunction occurred much earlier than NEDD dysfunction.

关键词

高胆固醇高脂血症血管功能内皮功能血管超声

Keywords

HypercholesterolenliaVascular functionEndothelial functionHigh - resolution ultrasound

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重庆医科大学基础医学院药理教研室

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