Activation and significance of NF -kBp65 on the lesion of glomerulus in active Heymann nephritis

DU Xiaogang; et al

doi:10.13406/j.cnki.cyxb.2003.01.007

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Activation and significance of NF -kBp65 on the lesion of glomerulus in active Heymann nephritis

更新时间：2024-01-17

- Activation and significance of NF -kBp65 on the lesion of glomerulus in active Heymann nephritis
- Journal of Chongqing Medical University Issue 1, Pages: 21-24(2003)
- 作者机构：
  
  1. 重庆医科大学临床学院肾内科
  2. 重庆医科大学临床学院肾内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2003.01.007
  CLC： R692.3
- Published：2003，
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[1]杜晓刚,甘华.NF-κBp65在主动性Heymann肾炎肾小球损伤中的作用[J].重庆医科大学学报,2003(01):21-24+31.

DU Xiaogang, et al. Activation and significance of NF -kBp65 on the lesion of glomerulus in active Heymann nephritis. [J]. Journal of Chongqing Medical University (1):21-24(2003)
[1]杜晓刚,甘华.NF-κBp65在主动性Heymann肾炎肾小球损伤中的作用[J].重庆医科大学学报,2003(01):21-24+31. DOI： 10.13406/j.cnki.cyxb.2003.01.007.

DU Xiaogang, et al. Activation and significance of NF -kBp65 on the lesion of glomerulus in active Heymann nephritis. [J]. Journal of Chongqing Medical University (1):21-24(2003) DOI： 10.13406/j.cnki.cyxb.2003.01.007.

摘要

目的:探讨主动性Heymann肾炎（AHN）肾小球内NF-κBp65的活化及意义。方法:8～10周龄Wistar雌性大鼠20只平均分2组

肾炎模型组予皮下免疫Fx1A/CFA

对照组予皮下注射CFA。免疫组化染色观察大鼠肾小球内NF-κBp65的活化及其与肾组织病理和生化指标改变的相互关系。结果:与对照组比较

肾炎模型组大鼠肾小球基底膜（GBM）明显增厚、肾小球NF-κBp65的活化明显增加

差异有显著性（P<0.01）;肾小球内NF-κBp65的活化与GBM增厚程度呈明显的直接正相关（P<0.05）。结论:NF-κBp65的活化参与了AHN的肾小球的病理损害过程。

Abstract

Objective:To study the activation and significance of NF- κBp65 in active Heymann nephritis in rats. Methods : Female Wistar rats 6~8 weeks of age were used. The nephritis was induced with FxIA/CFA by subcutaneous injection and the control group with CFA . After the rats were killed

the activation of NF- κBp65 in renal tissue was observed by use of immunohistochemical dyeing ;also observed were the changes in pathology

urinary protein and albumin and the relationship between these 3 factors. Results: Compared with the control group

the thickness of GBM increased (F<0.01)

as well as the activation of NF - κBp65 in renal tissue. A tight positive correlation was found between NF- κBp65 in glomerulus and the thickness of GBM. Conclusion :The activation of NF - κBp65 may play an important role in the pathological lesion in the glomerulus of AHN.

关键词

主动性Hymann肾炎肾小球核因子кB

Keywords

Active Heymann nephritisGlomerulusNuclear factor-κB

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