P-Transfer factor oral  solution  combined  with  Ketotifen  decreased the  incidence  of  asthma  following  bronchiolitis

HUANG Ying; et al

doi:10.13406/j.cnki.cyxb.2002.01.024

您当前的位置：

首页 >

文章列表页 >

P-Transfer factor oral solution combined with Ketotifen decreased the incidence of asthma following bronchiolitis

更新时间：2024-01-17

- P-Transfer factor oral solution combined with Ketotifen decreased the incidence of asthma following bronchiolitis
- Journal of Chongqing Medical University Issue 1, Pages: 74-75(2002)
- 作者机构：
  
  1. 重庆医科大学儿童医院呼吸科
  2. 重庆医科大学儿童医院呼吸科,重庆,400014
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2002.01.024
  CLC： R725.6
- Published：2002，
扫描看全文
[1]黄英,张儒谊,李渠北,何佳敏.P-转移因子联合酮替芬降低毛细支气管炎后支气管哮喘患病率的研究[J].重庆医科大学学报,2002(01):74-75+78.

HUANG Ying, et al. P-Transfer factor oral solution combined with Ketotifen decreased the incidence of asthma following bronchiolitis. [J]. Journal of Chongqing Medical University (1):74-75(2002)
[1]黄英,张儒谊,李渠北,何佳敏.P-转移因子联合酮替芬降低毛细支气管炎后支气管哮喘患病率的研究[J].重庆医科大学学报,2002(01):74-75+78. DOI： 10.13406/j.cnki.cyxb.2002.01.024.

HUANG Ying, et al. P-Transfer factor oral solution combined with Ketotifen decreased the incidence of asthma following bronchiolitis. [J]. Journal of Chongqing Medical University (1):74-75(2002) DOI： 10.13406/j.cnki.cyxb.2002.01.024.

摘要

目的：观察Ｐ－转移因子和酮替芬联合应用能否降低毛细支气管炎后支气管哮喘患病率。方法：５０例毛细支气管炎患儿采用口服Ｐ－转移因子进行免疫调节治疗并辅以酮替芬抗过敏，疗程３～６个月，临床随访≥１年，观察发生哮喘的例数。同时检测防治前后患儿血清ＩｇＥ、ＩｇＧ、ＩｇＡ、ＩｇＭ与Ｔ细胞亚群变化。４６例毛细支气管炎患儿不用药作为对照组。结果：完成随访　＞１年者，防治组４３例中仅２例（４．６５　％）发生哮喘，而对照组３９例中有１１例（２８．２１％）发生哮喘，两组有显著差异（Ｐ　＜０．０１）。防治组患儿免疫功能改善明显，ＩｇＥ水平，ＣＤ４／ＣＤ８比率下降，ＩｇＧ、ＩｇＡ、ＣＤ３水平增高，与防治前相比差异有显著性。结论：Ｐ　－转移因子联合酮替芬口服，可降低毛细支气管炎后支气管哮喘患病率。

Abstract

Objective: To evaluate the efficiency of P-transfer factor oral solution (P-TFO) combined with ketotifen (KTF) in decreasing the incidence of asthma following bronchiolitis. Methods: 50 patients with bronchiolitis were given P-TFO and KTF compared with 46 patients with bronchiolitis without the treatment of P-TFO and KTF. The total course was 3～6 months and the average time of follow up was 1 year. Serum level of IgE

IgG

IgA

IgM and T lymphocyte subsets were tested before and after the treatment. Results: After follow up over 1 year

2/46 (4.65%) of the patients with bronchiolitis receiving P-TFO and KTF developed asthma compared with 11/39 (28.21%) of the controls with bronchiolitis (P <0.01). The immune function of the patients with bronchiolitis receiving P-TFO and KTF improved. The serum level of IgE and the ratio of CD4/CD8 decreased

and the CD3

CD8 counts were increased after the treatment. Conclusion: P-TFO combined with KTF is an effective way to decrease the incidence of asthma following bronchiolitis.

关键词

毛细支气管炎P-转移因子酮替芬哮喘防治

Keywords

P-transfer factorKetotifenBronchiolitisasthmaPrevention and treatment

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Research progress in the diagnosis and treatment of non-eosinophilic asthma

Research progress of autophagy in lung inflammatory diseases

A prelminary observation of nitric oxide and forced expiratory volume on one second in patitnts with bronchal asthma

Determination of serum ET and TNF-a and its clinical significance in asthmatic children

Effects of house dust mite injected in neonate rats on airway inflammation and TH subset in later life

Related Author

Tang Lanfang

Wu Fang

Yuan Bin

Wu Demei

Lian Kang

Shao Zijian

Zhang Xinyue

Liu Qiong

Related Institution

Department of Respiratory Medicine，Children’s Hospital，Zhejiang University School of Medicine/ National Clinical Research Center for Child Health

Department of Pediatrics，The Affiliated Hospital of Nanjing University of Chinese Medicine，The First Clinical Medical College of Nanjing University of Chinese Medicine

Department of Traditional Chinese Medicine，Children’s Hospital，Zhejiang University School of Medicine/ National Clinical Research Center for Child Health

Department of Emergency and Critical Care Medicine,The First Affiliated Hospital of Chongqing Medical University

⁰