Objective: To evaluate the relationship between CD44 splice variant V6 (CD44v6) expression and carcinogensis and progression of cervical cancer. Methods: Immunohistochemistry was used to examine the CD44v6 protein expression in 10 cases of cervical squamous cell cancer

44 cases of dyspasia and 55 cases of cervical squamous cell cancer. Results: The CD44v6 positive rate was higher in cervical dyspasia than in normal cervical tissues (P <0.05). The positive rates of overexpression in cervical carcinoma in situ was higher than in dyspasia. The positive rates of expression CD44v6 in cancer were higher than in cervical carcinoma in situ (P< 0.05). The expression of CD44v6 protein showed difference between metastasis in lymph node and clinical stages of differentiation. Conclusion:The results indicated that the expression of CD44v6 may be linked with cervical tumourigenesis and progression. CD44v6 expression analysis could not only aid the early diagnosis of cervical cancer and its metastasis

but also beuseful as a prognostic indicator.