P16 and cyclinD<sub>1</sub> expression in carcinogenesis of gastric mucosa

XIAO Ning; et al

doi:10.13406/j.cnki.cyxb.2002.01.010

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P16 and cyclinD₁ expression in carcinogenesis of gastric mucosa

更新时间：2024-01-17

- P16 and cyclinD₁ expression in carcinogenesis of gastric mucosa
- Journal of Chongqing Medical University Issue 1, Pages: 32-34(2002)
- 作者机构：
  
  1. 重庆医科大学第二临床学院急诊科
  2. 重庆医科大学第二临床学院急诊科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2002.01.010
  CLC： R735.2
- Published：2002，
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[1]肖宁,吴小翎,李宇.胃粘膜癌变过程中P16、CyclinD_1的表达[J].重庆医科大学学报,2002(01):32-34.

XIAO Ning, et al. P16 and cyclinD₁ expression in carcinogenesis of gastric mucosa. [J]. Journal of Chongqing Medical University (1):32-34(2002)
[1]肖宁,吴小翎,李宇.胃粘膜癌变过程中P16、CyclinD_1的表达[J].重庆医科大学学报,2002(01):32-34. DOI： 10.13406/j.cnki.cyxb.2002.01.010.

XIAO Ning, et al. P16 and cyclinD₁ expression in carcinogenesis of gastric mucosa. [J]. Journal of Chongqing Medical University (1):32-34(2002) DOI： 10.13406/j.cnki.cyxb.2002.01.010.

摘要

目的：探讨Ｐ１６、ＣｙｃｌｉｎＤ１的表达在胃癌发生发展中的作用。方法：采用免疫组化Ｓ－Ｐ法。结果：在胃粘膜癌变过程中，Ｐ１６阳性表达率逐渐下降，其中异型增生和胃癌组Ｐ１６阳性表达率明显低于慢性浅表性胃炎组（Ｐ　＜０．０５）；ＣｙｃｌｉｎＤ１阳性表达率逐渐增高，其中肠化生、异型增生和胃癌组ＣｙｃｌｉｎＤ１阳性表达率明显高于慢性浅表性胃炎组（Ｐ　＜０．０５）。在胃癌中，Ｐ１６阳性表达率与胃癌分期和分化程度有关，ＣｙｃｌｉｎＤ１的阳性表达率与之无关。结论：Ｐ１６表达缺失和ＣｙｃｌｉｎＤ１异常表达是胃癌发生过程中一个较早的分子事件，且Ｐ１６表达缺失与胃癌进展和恶性程度有关。

Abstract

Objective: To study the role of P16 and cyclinD1 expression in the occurrence and development of gastric carcinoma. Methods: Using S-P immunohisto-chemistry. Results: With the progressing of gastric mucosa lesions

the positive rate of P16 expression had a decreasing tendency and on the other hand

that of cyclinD1 had an increasing tendency. The positive rate of P16 in the dysplasia and gastric cancer were much lower than that in the chronic superficial gastritis (P<0.05)

and was correlated with phase and degree of differentiation of gastric cancer. That of cyclinD1 in the intestinal metaplasia，dysplasia and gastric cancer was much higher than that in the chronic superficial gastritis (P<0.05)

and was not correlated with phase and degree of differentiation of gastric cancer. Conclusion: Deletion of P16 expression and abnormality of cyclinD1 expression are early molecular events

and the former is correlated with development and malignancy of gastric carcinoma.

关键词

P16Cyclin　D1胃癌癌前病变

Keywords

P16CyclinD1Precancerous lesionStomach neoplasms

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Department of Otorhinolaryngology, Second College of Clinical Medicine, Chongqing Medical University

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Department of Cardiothoracic Surgery, the First Affiliated Hospital, Chongqing Medical University

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P16 and cyclinD1 expression in carcinogenesis of gastric mucosa

DOI：10.13406/j.cnki.cyxb.2002.01.010

摘要

Abstract

关键词

Keywords

references

P16 and cyclinD₁ expression in carcinogenesis of gastric mucosa