Relation of myocardial remodeling and PDGF-B expression  after myocardial infarction

LIU Yuan-sheng; et al

doi:10.13406/j.cnki.cyxb.2001.04.007

您当前的位置：

首页 >

文章列表页 >

Relation of myocardial remodeling and PDGF-B expression after myocardial infarction

更新时间：2024-01-17

- Relation of myocardial remodeling and PDGF-B expression after myocardial infarction
- Journal of Chongqing Medical University Issue 4, Pages: 382-383(2001)
- 作者机构：
  
  1. 重庆医科大学临床学院心血管内科
  2. 重庆医科大学临床学院心血管内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2001.04.007
  CLC： R542.22
- Published：2001，
扫描看全文
[1]刘元生,陈运贞,王悦喜.心肌梗塞后心肌重塑与PDGF-B蛋白表达的相关性[J].重庆医科大学学报,2001(04):382-383.

LIU Yuan-sheng, et al. Relation of myocardial remodeling and PDGF-B expression after myocardial infarction. [J]. Journal of Chongqing Medical University (4):382-383(2001)
[1]刘元生,陈运贞,王悦喜.心肌梗塞后心肌重塑与PDGF-B蛋白表达的相关性[J].重庆医科大学学报,2001(04):382-383. DOI： 10.13406/j.cnki.cyxb.2001.04.007.

LIU Yuan-sheng, et al. Relation of myocardial remodeling and PDGF-B expression after myocardial infarction. [J]. Journal of Chongqing Medical University (4):382-383(2001) DOI： 10.13406/j.cnki.cyxb.2001.04.007.

摘要

目的：探讨心肌重塑与血小板源性生长因子（ＰＤＧＦ－Ｂ）蛋白表达的相关性。方法：建立Ｗｉｓｔａｒ大鼠心肌梗死后心肌重塑模型，用免疫组化和图像分析方法研究Ⅰ型，Ⅲ型胶原含量和ＰＤＧＦ－Ｂ表达的变化。结果：心肌Ⅰ型、Ⅲ型胶原含量和ＰＤＧＦ－Ｂ表达均增加，分别与假手术组比较均具有非常显著性差异（Ｐ＜０．０１）。Ⅰ型、Ⅲ型胶原含量与ＰＤＧＦ－β表达量正相关（Ｐ＜０．０１）。结论：心肌梗死后心肌重塑的机制可能是各种致病因素最终通过调节成纤维细胞ＰＤＦＧ－Ｂ表达实现的。

Abstract

Objective: To approach the relation of myocardial remodeling and expression of growth factor derived from platelet (PDGF-B) after myocardial infarction.Methods:Myocardial remodeling models o f myocardial infarction in Wistar rats were used to study expression changes of collagen subtype Ⅰ

Ⅲ and PDGF-B with immunohistochemistry and image analysis .Results: Cardiac collagen Ⅰ

Ⅲ and PDGF-B were increased (P＜0.01) in myocardial infarction groups compared with those in sham group.Collagen Ⅰ and collagen Ⅲ levels correlated positively to PDGF-B levels significantly (P＜0.01).Conclusion: Myocardial remodeling after myocardial infarction may be induced ultimately by PDGF-B expression of modulating fibroblast with various pathogenesis.

关键词

心肌梗死心肌重塑胶原血小板源性生长因子

Keywords

myocardial infarctionmyocardial remodelingCollagenPDGF-B

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

AT1-AA expression of patients with essential hypertension complicated with myocardial infarction and effect of AT1-AA on the coronary artery in rats

Protection and mechanism of zinc sulfate combined with aspirin for acute myocardial infarction

THE ALTERATIONS OF RENAL AND HEMODYNAMIC EFFECTS OF NATRIURETIC FACTOR IN ATRIA OF THE RATS WITH ACUTE HEART FAILURE

The study of remodeling of myocardium mesenchyme in spontaneous hypertensive rats

Experimental study for reversion of ventricular remodeling by enalapril or fosinopril in spontaneously hypertensive rats

Related Author

Li Yanming

Zhong Xiaoming

Zhang Yuan

Fu Hairong

Department of Pathophysiology Du Xiaojun

陈运贞

李法琦

雷寒

Related Institution

Department of Cardiovascular Medicine,Huaihe River Hospital of Henan University

Chongqing Three Gorges Medical College

重庆医科大学病理生理学教研室

重庆医科大学第二临床学院心血管内科

重庆医科大学基础医学院病理教研室

⁰