The immunoenhancement of thymopentin (TP-5) for chemotherapeutical tumour patients

ZHANG Xing-ping; et al

doi:10.13406/j.cnki.cyxb.2001.03.024

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The immunoenhancement of thymopentin (TP-5) for chemotherapeutical tumour patients

更新时间：2024-01-17

- The immunoenhancement of thymopentin (TP-5) for chemotherapeutical tumour patients
- Journal of Chongqing Medical University Issue 3, Pages: 299-301(2001)
- 作者机构：
  
  1. 重庆医科大学临床学院肿瘤科
  2. 重庆医科大学临床学院肿瘤科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2001.03.024
  CLC： R730.5
- Published：2001，
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[1]张幸平,雷自重,陈绪元,张涛,赵斌,戴晓波.注射用胸腺五肽(TP-5)对肿瘤化疗病人的免疫增强作用[J].重庆医科大学学报,2001(03):299-301.

ZHANG Xing-ping, et al. The immunoenhancement of thymopentin (TP-5) for chemotherapeutical tumour patients. [J]. Journal of Chongqing Medical University (3):299-301(2001)
[1]张幸平,雷自重,陈绪元,张涛,赵斌,戴晓波.注射用胸腺五肽(TP-5)对肿瘤化疗病人的免疫增强作用[J].重庆医科大学学报,2001(03):299-301. DOI： 10.13406/j.cnki.cyxb.2001.03.024.

ZHANG Xing-ping, et al. The immunoenhancement of thymopentin (TP-5) for chemotherapeutical tumour patients. [J]. Journal of Chongqing Medical University (3):299-301(2001) DOI： 10.13406/j.cnki.cyxb.2001.03.024.

摘要

目的：验证注射用胸腺五肽（ＴＰ－５）对肿瘤化疗病人免疫功能低下治疗的临床疗效及安全性。方法：３０例恶性肿瘤患者随机分为试验组（化疗加ＴＰ－５）及对照组（化疗加安慰剂）。ＴＰ－５及安慰剂与化疗同时开始使用，每日肌注一次，共用２８天。定期检查血常规、免疫学指标、肝肾功能及ＥＣＧ。结果：试验组有效率为１００％，对照组有效率为２６．７％（Ｐ＜０．０５）。未发现与ＴＰ－５有关的肝肾功能损害及ＥＣＧ改变。结论：ＴＰ－５具有改善肿瘤化疗病人细胞免疫功能的作用，临床应用安全可靠。

Abstract

Objective:To observe the therapeutic effectiveness a nd the safety coefficient of the thymopentin injection (TP-5) for chemotherapy of tumour patients with hypoimmunity. Methods:Thirty malignan t tumour patients were randomly divided into two groups:test group (chemotherapy combined with TP-5) and contrast group (chemotherapy combined with placebo). TP -5 and placebo were used while chemotherapy by intramuscular injection daily for 28 days. The blood routine examination、immunologic condition、liver function、 renal function and ECG were tested regularly. Results :The efficac y rate of the patients with TP-5 was 100%

but 26.7% (P＜0.05) w ith placebo. The injury of liver function、renal functin and ECG with TP-5 were not observed.Conclusion:TP-5 can improve the cell-immunologic func tion of tumour patients during chemotherapy.It was effective and safe in the clinical application.

关键词

注射用胸腺五肽免疫增强作用肿瘤化疗

Keywords

Thymopentin for injection (TP-5)ImmunoenhancementTumour ch emotherapy.

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