Efficacy and safety of glimepiride in the treatment of patients with type 2 diabetes mellitus

doi:10.13406/j.cnki.cyxb.2001.03.010

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Efficacy and safety of glimepiride in the treatment of patients with type 2 diabetes mellitus

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- Efficacy and safety of glimepiride in the treatment of patients with type 2 diabetes mellitus
- Journal of Chongqing Medical University Issue 3, Pages: 253-256(2001)
- 作者机构：
  
  1. 重庆医科大学临床学院内分泌科
  2. 重庆建设医院
  3. 重庆钢铁公司总医院
  4. 重庆医科大学临床学院内分泌科,重庆,400016
  5. ,重庆,400084
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2001.03.010
  CLC： R587.1
- Published：2001，
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[1]李启富,张素华,李萍,王丽,刘红,龚涛,舒昌达.格列美脲治疗2型糖尿病的临床效果及安全性[J].重庆医科大学学报,2001(03):253-256.

Efficacy and safety of glimepiride in the treatment of patients with type 2 diabetes mellitus. [J]. Journal of Chongqing Medical University (3):253-256(2001)
[1]李启富,张素华,李萍,王丽,刘红,龚涛,舒昌达.格列美脲治疗2型糖尿病的临床效果及安全性[J].重庆医科大学学报,2001(03):253-256. DOI： 10.13406/j.cnki.cyxb.2001.03.010.

Efficacy and safety of glimepiride in the treatment of patients with type 2 diabetes mellitus. [J]. Journal of Chongqing Medical University (3):253-256(2001) DOI： 10.13406/j.cnki.cyxb.2001.03.010.

摘要

目的：观察国产格列美脲（ＧＭＤ）的降糖效果和安全性，并与进口ＧＭＤ比较。方：５６例２型糖尿病患者经２周平衡期后随机分为Ａ组和Ｂ组，分别给国产ＧＭＤ（普糖平）、进口ＧＭＤ（Ａｍａｒｙｌ）治疗８周。结果：无论是Ａ组还是Ｂ组，治疗８周末空腹血糖（ＦＰＧ）、餐后２ｈ血糖（ＰＰＧ）、糖化血红蛋白（ＨｂＡ１ｃ）显著下降（Ｐ＜０．００１）；ＦＰＧ、ＨｂＡ１ｃ下降值两组之间比较无明显差异（Ｐ＞０．０５），但ＰＰＧ下降值Ｂ组高于Ａ组（Ｐ＜０．０５）；治疗后两组患者空腹和餐后２ｈ血胰岛素均升高，尤以餐后２ｈ血胰岛素升高更明显（Ｐ＜０．００１），但两组之间比较无明显差异（Ｐ＞０．０５）；治疗后两组患者血Ｃ－肽、血脂、肝肾功等无明显变化；Ａ组、Ｂ组患者均无低血糖发生，少数患者出现嗜睡，但程度均不重。结论：国产ＧＭＤ是一种安全、疗效确切的降糖新药。

Abstract

Objective： To assess the efficacy and safety of do mestic glimepiride (Putangping) in patients with type 2 diabetes mellitus

in comparison with that of glimepiride (Amary1).Methods： After a two-week washout period

56 patients with type 2 diabetes mellitus were randomized into two groups

Group A and Group B

receiving Putangping and Amary1 respectively for 8 weeks.Results： At endpoint

fasting plasma glucose (FPG)

two-hour postprandial plasma glucose(PPG) and HbA1c decreased significantly in both Group A and Group B(P＜0.001). Changes of FPG and HbA1c from baseline to endpoint between the two groups were similar (P＞0.05)

but PPG decreased from baseline to endpoint in Group B exceeded that in Group A (P＜0.05). Fasting and postprandial insulin in both groups increased after the treatment

which was especially obvious for postprandial insulin (P＜0.001).There were no meaningful difference in C-peptide

lipoprotein

hepatic and renal function in the two groups after the trea tment. No hypoglycemia occurred. The incidence of dizziness was similar in both groups .Conclusion： Glimepiride (Petangping) is safe and effective for the treatment of patients with type 2 diabetes mellitus.

关键词

格列美脲（GMD）2型糖尿病

Keywords

Glimepiridetype 2 diabetes

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